1029019-98-4

Upstream product

• 1029019-96-2 tert-butyl N-(5-oxopentyl)-N-[(R)-(1-phenylethyl)]carbamate 
• 134833-70-8 dimethyl [2-(methoxy(methyl)amino)-2-oxoethyl]phosphonate 

Downstream Products

• 1029020-00-5 N-methoxy-N-methyl (2R)-1-[(1R)-1-phenylethyl]piperidine-2-acetamide 
• 1029019-93-9 N-methoxy-N-methyl (2S)-1-[(1R)-1-phenylethyl]piperidine-2-acetamide 

Relevant academic research and scientific papers

Asymmetric aza-Michael addition: synthesis of (-)-allosedridine and (-)-2-epi-ethylnorlobelol

The combination of cross-metathesis and aza-Michael addition is an efficient method for generating piperidine alkaloids. Allosedridine and 2-epi-ethylnorlobelol were synthesized in six steps with ca. 25% overall yield. The aza-Michael addition is reversible for phenyl and alkyl ketones; however, the epimerization is not observed for the corresponding ester and amide.