1029083-72-4Relevant academic research and scientific papers
Synthesis of the C7-26 fragment of amphidinolides G and H
Hara, Akihiro,Morimoto, Ryo,Ishikawa, Yuichi,Nishiyama, Shigeru
, p. 4036 - 4039 (2011/10/04)
A new approach to the synthesis of the C7-26 fragment of amphidinolides G and H was developed. In the sequence, the C7-18 portion of this fragment was synthesized using an acetylide coupling protocol, while an Evans alkylation and Sharpless asymmetric dihydroxylation were employed as key steps in construction of the C19-26 subfragment. Finally, both of these units were joined by utilizing an aldol coupling reaction to produce the target C7-26 fragment in good yield.
Synthesis of the bis-spiroacetal core of the antimitotic agent spirastrellolide B
Chen, Jack Li-Yang,Brimble, Margaret A.
experimental part, p. 9417 - 9428 (2012/01/13)
The spirastrellolides are a family of potent antimitotic agents isolated from the marine sponge Spirastrella coccinea. Synthetic studies toward the DEF bis-spiroacetal core of spirastrellolide B are reported. A modular approach was pursued by the use of t
Synthesis of the bis-spiroacetal C25-C40 moiety of the antimitotic agent spirastrellolide B using a bis-dithiane deprotection/spiroacetalisation sequence
Chen, Jack Li-Yang,Brimble, Margaret A.
scheme or table, p. 3967 - 3969 (2010/07/07)
Use of a bis-dithiane deprotection-tandem bis-spiroacetalisation sequence was key to the successful synthesis of the [5,6,6]-bis-spiroacetal of the antimitotic agent spirastrellolide B, achieved in a highly convergent fashion involving successive dithiane alkylations.
Synthetic studies toward halichlorine: Complex azaspirocycle formation with use of an NBS-promoted semipinacol reaction
Hurley, Paul B.,Dake, Gregory R.
, p. 4131 - 4138 (2008/09/21)
(Chemical Equation Presented) The investigations of a synthetic route incorporating a NBS-promoted semipinacol rearrangement to the 6-azaspiro[4.5]decane fragment within halichlorine (1) are presented. A convergent approach was pursued, utilizing two chir
