242808-65-7

Upstream product

• 158817-21-1 (E)-5-(4-methoxybenzyloxy)pent-2-en-1-ol 
• 2746-25-0 p-Methoxybenzyl bromide 
• 146916-74-7 C₁₃H₁₈O₃ 
• 201667-72-3 methyl (2E)-5-(4-methoxybenzyloxy)-2-pentenoate 
• 135362-69-5 3-(4-methoxybenzyl)oxypropan-1-ol 
• 824-94-2 p-methoxybenzyl chloride 
• 128461-65-4 3-(p-methoxybenzyloxy)propanal 
• 218434-90-3 1-but-3-ynyloxymethyl-4-methoxy-benzene 
• 146916-76-9 5-(4-methoxyphenyl)methoxy-2-pentyn-1-ol 

Downstream Products

• 338956-95-9 (2S,3R)-2-iodomethyl-3-[2-(4-methoxybenzyloxy)ethyl]oxirane 
• 444809-59-0 (2S,3R)-2-Chloromethyl-3-[2-(4-methoxy-benzyloxy)-ethyl]-oxirane 
• 1029083-72-4 (2S,3S)-5-(4-methoxybenzyloxy)-3-methylpentane-1,2-diol 
• 1033074-47-3 (S)-1-((5,5-dibromo-3-methylpent-4-enyloxy)methyl)-4-methoxybenzene 
• 1033074-22-4 (S)-1-methoxy-4-((3-methylpent-4-ynyloxy)methyl)benzene 
• 1315317-40-8 (3S,8S,E)-12-(tert-butyldiphenylsiloxy)-1-(4-methoxybenzyloxy)-3,8-dimethyldodec-10-en-4-yn-6-one 
• 1315317-41-9 (7S,12S,E)-3,3-diethyl-7,12,19,19-tetramethyl-18,18-diphenyl-4,17-dioxa-3,18-disilaicos-14-en-8-yn-10-one 
• 1315317-50-0 C₃₀H₄₀O₃Si 
• 1315317-42-0 (7S,8E,12S,14E)-3,3-diethyl-7,8,12,19,19-pentamethyl-18,18-diphenyl-4,17-dioxa-3,18-disilaicosa-8,14-dien-10-one 
• 1315317-43-1 (6E,9S,12E,14S)-18,18-diethyl-2,2,9,13,14-pentamethyl-11-methylene-3,3-diphenyl-4,17-dioxa-3,18-disilaicosa-6,12-diene 
• 1315317-51-1 (3S,4E,8S,10E)-12-(tert-butyldiphenylsilyloxy)-3,4,8-trimethyl-6-methylenedodeca-4,10-dien-1-ol 
• 1315317-36-2 (3S,4E,8S,10E)-12-(tert-butyldiphenylsilyloxy)-3,4,8-trimethyl-6-methylenedodeca-4,10-dienal 
• 1315317-47-5 (6R,8R,9S,10R,13S,15S,16E,20S,22E)-6,9,10-tris(tert-butyldimethylsiloxy)-13-hydroxy-2,2,3,3,8,15,16,20,27,27-decamethyl-18-methylene-26,26-diphenyl-4,25-dioxa-3,26-disilaoctacosa-16,22-dien-11-one 
• 1315317-48-6 (6R,8R,9S,10R,13R,15S,16E,20S,22E)-6,9,10-tris(tert-butyldimethylsiloxy)-13-hydroxy-2,2,3,3,8,15,16,20,27,27-decamethyl-18-methylene-26,26-diphenyl-4,25-dioxa-3,26-disilaoctacosa-16,22-dien-11-one 

Relevant academic research and scientific papers

Synthesis of the spiroketal core of integramycin

A concise synthetic strategy towards the spiroketal core of the HIV-integrase inhibitor integramycin (1) was developed. The required ketone precursor was efficiently constructed from two simple and easily accessible subunits by means of a hydrozirconation/copper catalyzed acylation reaction. The effects of different protecting groups on the spiroketalization step were also investigated.

Asymmetric syntheses of all stereoisomers of 3-hydroxyproline; A constituent of several bioactive compounds

Synthesis of an unusual β-hydroxy-α-amino acid, 3-hydroxyproline, and its derivatives have been achieved enantioselectively by employing Sharpless asymmetric epoxidation and reductive cyclization as the key steps. Georg Thieme Verlag Stuttgart ? New York.

Synthesis of the C7-26 fragment of amphidinolides G and H

A new approach to the synthesis of the C7-26 fragment of amphidinolides G and H was developed. In the sequence, the C7-18 portion of this fragment was synthesized using an acetylide coupling protocol, while an Evans alkylation and Sharpless asymmetric dihydroxylation were employed as key steps in construction of the C19-26 subfragment. Finally, both of these units were joined by utilizing an aldol coupling reaction to produce the target C7-26 fragment in good yield.

Synthesis of the bis-spiroacetal C25-C40 moiety of the antimitotic agent spirastrellolide B using a bis-dithiane deprotection/spiroacetalisation sequence

Use of a bis-dithiane deprotection-tandem bis-spiroacetalisation sequence was key to the successful synthesis of the [5,6,6]-bis-spiroacetal of the antimitotic agent spirastrellolide B, achieved in a highly convergent fashion involving successive dithiane alkylations.

Stereoconvergent synthesis of the C1-C11 and C12-C24 fragments of (-)-macrolactin-A

Stereoconvergent syntheses of the C1-C11 and C12-C24 fragments of (-)-macrolactin-A are reported.

Pestalotiopsin A. Side chain installation and exhaustive probing of olefin metathesis as a possible tool for elaborating the cyclononene ring

(Chemical Equation Presented) A program directed toward an asymmetric synthesis of pestalotiopsin A is described. The routing begins with the dextrorotatory cyclobutanol 37, which is combined with the enantiomerically defined building blocks ent-15 and 16

A convergent approach for the total synthesis of (-)-synrotolide diacetate

A simple carbohydrate based convergent approach towards the total synthesis of (-)-synrotolide diacetate is described employing a Sharpless asymmetric epoxidation, a Grignard assisted lactol opening with a terminal alkyne and a Wittig reaction using the H

Asymmetric synthesis of ( - )-7-epiaustraline and (+)-1,7-diepiaustraline

A diastereoselective and modular approach to the synthesis of the 3-hydroxymethyl-2,3,5,6,7,7a-hexahydro-1H-pyrrolizine-1,2,7-triol structure, characteristic of several natural pyrrolizidine natural products, has been developed. This approach culminated i

Synthesis and evaluation of A-ring diastereomers of 1α,25-dihydroxy-22-oxavitamin D3 (OCT)

A-ring diastereomers of 1α,25-dihydroxy-22-oxavitamin D3 (OCT) (2), 3-epi-1α,25-dihydroxy-22-oxavitamin D3 (3-epiOCT) (3) and 1,3-diepi-1α,25-dihydroxy-22-oxavitamin D3 (1,3-diepiOCT) (4) were synthesized by the convergent method. In vitro binding affinity for rat vitamin D binding protein and calf-thymus vitamin D receptor, differentiation-inducing activity on HL-60 cells, and transcriptional activity of 3-epiOCT (3) and 1,3-diepiOCT (4) were evaluated in comparison with OCT (2), 1-epi-1α,25-dihydroxy-22-oxavitamin D3 (1-epiOCT) (5) and 1α,25-dihydroxyvitamin D3 (1).

Synthetic studies on ciguatoxin [1]; construction of the spiro acetal part (C46-C55)

The spiro acetal part (C46-C55) of ciguatoxin was synthesized stereoselectively.