1029289-40-4Relevant academic research and scientific papers
Stereodivergent catalytic doubly diastereoselective nitroaldol reactions using heterobimetallic complexes
Sohtome, Yoshihiro,Kato, Yuko,Handa, Shinya,Aoyama, Naohiro,Nagawa, Keita,Matsunaga, Shigeki,Shibasaki, Masakatsu
supporting information; experimental part, p. 2231 - 2234 (2009/05/11)
(Chemicall Equation Presented) Stereodivergent construction of three contiguous stereocenters in catalytic doubly diastereoselective nitroaldol reactions of α-chiral aldehydes with nitroacetaldehyde dimethyl acetal using two types of heterobimetallic catalysts is described. A La-Li-BINOL (LLB) catalyst afforded anti,syn-nitroaldol products in >20:1-14:1 selectivity, and a Pd/La/Schiff base catalyst afforded complimentary syn,syn-nitroaldol products in 10:1-5:1 selectivity.
