1029317-23-4

Upstream product

• 31938-07-5 (3-bromophenyl)acetonitrile 
• 245439-36-5 4-(3-Bromo-phenyl)-tetrahydro-pyran-4-carbonitrile 
• 329025-26-5 tetrahydro-4-(3-bromophenyl)-2H-pyran-4-carboxamide 
• 156275-96-6 triisopropylsilanethiol 

Downstream Products

• 1029317-24-5 4-{3-[(4-acetyl-3-fluorophenyl)thio]phenyl}tetrahydro-2H-pyran-4-carboxamide 
• 1029317-21-2 4-(3-([4-(1-methyl-1H-pyrazol-5-yl)phenyl]thio)phenyl)tetrahydro-2H-pyran-4-carboxamide 
• 1159186-37-4 4-{3-[(4-acetylphenyl)thio]phenyl}tetrahydro-2H-pyran-4-carboxamide 
• 1159186-47-6 4-{3-[(4-bromo-2-chlorophenyl)thio]phenyl}tetrahydro-2H-pyran-4-carboxamide 
• 1159186-45-4 4-{3-[(4-acetyl-2-fluorophenyl)thio]phenyl}tetrahydro-2H-pyran-4-carboxamide 
• 1159185-76-8 4-{3-[3-fluoro-4-(2-methyl-2H-pyrazol-3-ylmethyl)phenylsulfanyl]phenyl}tetrahydro-pyran-4-carboxylic acid amide 
• 1159185-77-9 4-[3-({4-[(1-methyl-1H-pyrazol-5-yl)carbonyl]phenyl}thio)phenyl]tetrahydro-2H-pyran-4-carboxamide 
• 1159185-78-0 4-[3-({4-[(1-methyl-1H-pyrazol-5-yl)methyl]phenyl}thio)phenyl]tetrahydro-2H-pyran-4-carboxamide 
• 1159185-79-1 4-[3-({3-chloro-4-[(1-methyl-1H-pyrazol-5-yl)carbonyl]phenyl}thio)phenyl]tetrahydro-2H-pyran-4-carboxamide 
• 1159185-80-4 4-[3-({4-[(1-methyl-1H-pyrazol-5-yl)carbonyl]-3-(trifluoromethyl)phenyl}thio)phenyl]tetrahydro-2H-pyran-4-carboxamide 
• 1159185-96-2 4-[3-({3-cyano-4-[(1-methyl-1H-pyrazol-5-yl)oxy]phenyl}thio)phenyl]tetrahydro-2H-pyran-4-carboxamide 
• 1159185-41-7 4-(3-{[3-chloro-4-(1-methyl-1H-pyrazol-5-yl)phenyl]thio}phenyl)tetrahydro-2H-pyran-4-carboxamide 
• 1159185-42-8 4-(3-{[3-cyano-4-(1-methyl-1H-pyrazol-5-yl)phenyl]thio}phenyl)tetrahydro-2H-pyran-4-carboxamide 
• 1159185-52-0 4-(3-{[5-chloro-6-(1-methyl-1H-pyrazol-5-yl)pyridin-3-yl]thio}phenyl)tetrahydro-2H-pyran-4-carboxamide 

Relevant academic research and scientific papers

Development an efficient route to the 5-lipoxygenase inhibitor PF-04191834

A convergent six-step process for the synthesis of PF-04191834 (1), a potent and selective 5-lipoxygenase inhibitor, has been developed and used to deliver over 20 kg of API. The process uses the same bond-forming steps as the initial medicinal chemistry

PYRAZOLE DERIVATIVES AS 5-LO INHIBITORS

The invention relates to compounds of formula (I) processes for their preparation, their use as 5-lipoxygenase inhibitors and pharmaceutical compositions containing the same.

Pyrazole Analogs

The invention relates to the compounds of formula (I): or a pharmaceutically acceptable salt and solvate thereof, wherein R1 is F or H and to processes for the preparation of, intermediates used in the preparation of, compositions containing th