1029317-23-4Relevant articles and documents
Development an efficient route to the 5-lipoxygenase inhibitor PF-04191834
De Koning, Pieter D.,Murtagh, Lorraine,Lawson, Jon P.,Vonder Embse, Richard A.,Kunda, Sastry A.,Kong, Wei
, p. 1046 - 1051 (2011)
A convergent six-step process for the synthesis of PF-04191834 (1), a potent and selective 5-lipoxygenase inhibitor, has been developed and used to deliver over 20 kg of API. The process uses the same bond-forming steps as the initial medicinal chemistry
PYRAZOLE DERIVATIVES AS 5-LO INHIBITORS
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Page/Page column 65-66, (2009/07/03)
The invention relates to compounds of formula (I) processes for their preparation, their use as 5-lipoxygenase inhibitors and pharmaceutical compositions containing the same.
Pyrazole Analogs
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Page/Page column 16, (2008/12/05)
The invention relates to the compounds of formula (I): or a pharmaceutically acceptable salt and solvate thereof, wherein R1 is F or H and to processes for the preparation of, intermediates used in the preparation of, compositions containing th