1331755-98-6Relevant articles and documents
Development an efficient route to the 5-lipoxygenase inhibitor PF-04191834
De Koning, Pieter D.,Murtagh, Lorraine,Lawson, Jon P.,Vonder Embse, Richard A.,Kunda, Sastry A.,Kong, Wei
, p. 1046 - 1051 (2012/01/04)
A convergent six-step process for the synthesis of PF-04191834 (1), a potent and selective 5-lipoxygenase inhibitor, has been developed and used to deliver over 20 kg of API. The process uses the same bond-forming steps as the initial medicinal chemistry