1029325-06-1Relevant articles and documents
Synthesis of β- and γ-oxa isosteres of fosmidomycin and FR900098 as antimalarial candidates
Haemers, Timothy,Wiesner, Jochen,Giessmann, Dirk,Verbrugghen, Thomas,Hillaert, Ulrik,Ortmann, Regina,Jomaa, Hassan,Link, Andreas,Schlitzer, Martin,Van Calenbergh, Serge
, p. 3361 - 3371 (2008/09/20)
To expand the structure-activity relationships of fosmidomycin and FR900098, two potent antimalarials interfering with the MEP-pathway, we decided to replace a methylene group in β-position of the phosphonate moiety of these leads by an oxygen atom. β-oxa