183991-46-0Relevant academic research and scientific papers
Synthesis of new sulfonyloximes and their use in free-radical olefin carbo-oximation
Ovadia, Benjamin,Robert, Frédéric,Landais, Yannick
, p. 1958 - 1961 (2015)
New bifunctional reagents for free-radical carbo-oximation of olefins have been developed. In this process, a single reagent can act both as a trap for nucleophilic radicals as well as a source of electrophilic radical via an α-scission of an alkylsulfonyl radical. This strategy involving the addition of a C-centered electrophilic radical and an oxime across the double bond of an electron-rich alkene is initiated with a t-BuO radical following an unusual mechanism, supported by both experiments and density functional theory calculations.
GONADOTROPIN RELEASING HORMONE RECEPTOR ANTAGONISTS, METHOD FOR THE PREPARATION THEREOF AND PHARMACEUTICAL COMPOSITION COMPRISING THE SAME
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Paragraph 0360; 0361; 0362, (2015/06/24)
Disclosed are a gonadotropin releasing hormone receptor antagonist and a pharmaceutical composition including the same, which can be useful in preventing or treating a sex hormone-related disease such as endometriosis, amenorrhea, irregular menstruation, uterine myoma, uterine fibroids, polycystic ovarian disease, lupus erythematous, hypertrichosis, precocious puberty, short stature, acne, alopecia, gonadal steroid-dependent neoplasms, gonadotropin-producing pituitary adenoma, sleep apnea, irritable bowel syndrome, premenstrual syndrome, benign prostatic hyperplasia, contraception, and infertility, as well as Alzheimer disease.
GONADOTROPIN RELEASING HORMONE RECEPTOR ANTAGONISTS, METHOD FOR THE PREPARATION THEREOF AND PHARMACEUTICAL COMPOSITION COMPRISING THE SAME
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Page/Page column 69, (2013/09/12)
The present invention provides gonadotropin releasing hormone receptor antagonists and the pharmaceutical composition comprising the same, which can be useful in preventing or treating a sex hormone-related disease such as endometriosis, amenorrhea, irregular menstruation, uterine myoma, uterine fibroids, polycystic ovarian disease, lupus erythematous, hypertrichosis, precocious puberty, short stature, acne, alopecia, gonadal steroid-dependent neoplasms, gonadotropin-producing pituitary adenoma, sleep apnea, irritable bowel syndrome, premenstrual syndrome, benign prostatic hyperplasia, contraception, and infertility, as well as Alzheimer disease
Design, synthesis and antibacterial activity of novel N-formylhydroxylamine derivatives as PDF inhibitors
Yin,Jia,Zhao,Xu,Tang,Wang
experimental part, p. 695 - 703 (2011/07/29)
A new series of N-formylhydroxylamines 11a-i have been synthesized through a multi-step protocol starting from diethyl malonate. These compounds have been structurally characterized by IR, 1H NMR and HRMS. All the synthesized compounds 11a-i have been screened for antibacterial activities. All the compounds are found to exhibit potent in vitro inhibitory activity against Staphylococcus aureus and relatively weak antibacterial activity against Klebsiella pneumoniae.
Synthesis and antimicrobial activities of novel peptide deformylase inhibitors
Yin, Ling,Xu, Wei-Ren,Wang, Zhi-Guo,Zhang, Da-Tong,Jia, Jiong,Ge, Yan-Qing,Li, Yan,Wang, Jian-Wu
experimental part, p. 196 - 205 (2010/10/19)
A new series of N-formylhydroxylamine compounds were designed, optimized with the AutoDock 4.0.1to investigate the interactions between the target compounds and the amino acid residues of the Escherichia coli PDF?Ni enzyme, and then synthesized through mu
Synthesis of β- and γ-oxa isosteres of fosmidomycin and FR900098 as antimalarial candidates
Haemers, Timothy,Wiesner, Jochen,Giessmann, Dirk,Verbrugghen, Thomas,Hillaert, Ulrik,Ortmann, Regina,Jomaa, Hassan,Link, Andreas,Schlitzer, Martin,Van Calenbergh, Serge
, p. 3361 - 3371 (2008/09/20)
To expand the structure-activity relationships of fosmidomycin and FR900098, two potent antimalarials interfering with the MEP-pathway, we decided to replace a methylene group in β-position of the phosphonate moiety of these leads by an oxygen atom. β-oxa
Peptide deformylase inhibitors
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, (2008/06/13)
PDF inhibitors and novel methods for their use are provided.
Hydroximic acid derivatives
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, (2008/06/13)
Hydroximic acid derivatives, useful as pesticides, have the formula STR1 in which G is G1 or G2 having the formula: STR2 in which R4 and R5 are each lower alkyl; W is O, S, SO or SO2 ; X1, X2 and Xsu
