1029413-53-3

Usage

Uses

Used in Pharmaceutical Industry:
4-Amino-1-(1-Boc-pyrrolidin-3-yl)-1H-pyrazole is used as a building block for the synthesis of various pharmaceutical compounds. Its unique structure allows it to be a versatile intermediate in the development of new drugs, particularly those targeting the central nervous system or having potential anti-inflammatory, analgesic, or antipyretic properties.
Used in Chemical Research:
In the field of chemical research, 4-Amino-1-(1-Boc-pyrrolidin-3-yl)-1H-pyrazole serves as a valuable starting material for the preparation of a wide range of pyrazole-based derivatives. These derivatives can be further modified and studied for their potential applications in various chemical and biological processes.
Used in Material Science:
4-Amino-1-(1-Boc-pyrrolidin-3-yl)-1H-pyrazole can also be utilized in the development of novel materials with specific properties, such as those with enhanced conductivity, magnetism, or optical characteristics. The compound's ability to form stable complexes with various metal ions makes it a promising candidate for the creation of new materials with tailored properties.

Upstream product

• 1056024-38-4 tert-butyl 3-(4-nitro-1H-pyrazol-1-yl)pyrrolidine-1-carboxylate 
• 103057-44-9 N-(tert-butoxycarbonyl)-3-hydroxypyrrolidine 
• 141699-57-2 3-methanesulfonyloxy-pyrrolidine-1-carboxylic acid tert-butyl ester 
• 24424-99-5 di-tert-butyl dicarbonate 
• 34619-03-9 tert-butyldicarbonate 

Downstream Products

• 1428774-43-9 C₂₂H₂₃N₉O₂ 
• 1428775-82-9 N-{3-[(2-{[1-(1-methylpyrrolidin-3-yl)-1H-pyrazol-4-yl]amino}-9-{[2-(trimethylsilyl)ethoxy]methyl}-9H-purin-6-yl)oxy]phenyl}prop-2-enamide 

Relevant academic research and scientific papers

ATF6 MODULATORS AND USES THEREOF

Compounds (1-2) as modulators of Activating Transcription Factor 6 (ATF6) are provided. The compounds may find use as therapeutic agents for the treatment of diseases or disorders mediated by ATF6 and may find particular use in the treatment of viral infections, neurodegenerative diseases, vascular diseases, or cancer. (Formula (1-2))

Substituted heteroaryl compounds and composition thereof, and applicaitons of compounds and composition

The invention provides substituted heteroaryl compounds and a composition thereof, and applicaitons of the compounds and the composition. The compounds are compounds represented by the formula (I) or the formula (II) or stereoisomers, tautomers, nitrogen oxides, solvates, metabolites, pharmaceutically acceptable salts or prodrugs of the compounds represented by the formula (I) or the formula (II). The invention also provides the pharmaceutical composition comprising the compounds; the compounds and the pharmaceutical composition can adjust the activity of protein kinase, and are used for prevention, processing, treatment and remission of diseases or disorders mediated by the protein kinase.

SUBSTITUTED HETEROARYL COMPOUNDS AND METHODS OF USE

The present invention provides novel heteroaryl compounds, pharmaceutical acceptable salts and formulations thereof. They are useful in preventing, managing, treating or lessening the severity of a protein kinase-mediated disease. The invention also provides pharmaceutically acceptable compositions comprising such compounds and methods of using the compositions in the treatment of protein kinase-mediated disease.

BENZONITRILE DERIVATIVES AS KINASE INHIBITORS

Compounds of the formula I, in which R1, R2, X and Y have the meanings indicated in Claim 1, are inhibitors of TBK1 and IKKε and can be employed, inter alia, for the treatment of cancer and inflammatory diseases.

PYRIMIDINE INHIBITORS OF KINASES

The present invention relates to compounds of formula (I) or pharmaceutical acceptable salts, wherein A1, A2, A3, A4, X and Y are defined in the description. The present invention relates also to methods of making said compounds, and compositions containing said compounds which are useful for inhibiting kinases such as aurora and KDR.

A practical, two-step synthesis of 1-alkyl-4-aminopyrazoles

A novel synthesis of N1 alkyl-substituted pyrazoles with a free amino group at the C4 position is described. Commercially available 4-nitropyrazole was found to readily undergo Mitsunobu reactions with primary and secondary alcohols. Subsequent reduction of the nitro group via hydrogenation affords 1-alkyl-4-aminopyrazoles, which are valuable intermediates in the synthesis of pharmaceutically active compounds.