10295-46-2Relevant academic research and scientific papers
Synthesis of α-Hydroxycarboxylic Acid Anilides via Copper-Catalyzed C-N Coupling of α-Hydroxyamides with Aryl Halides
Li, Zhijie,Wen, Quan,Zhou, Lihong,Deng, Xingmei,Zeng, Qingle
, p. 3751 - 3757 (2015)
The synthesis of highly important α-hydroxycarboxylic acid anilides via copper-catalyzed chemoselective C-N coupling reactions of α-hydroxyamides and aryl halides is described. This highly selective N-arylation process demonstrates wide substrate scope, c
Zirconium-MOF-catalysed selective synthesis of α-hydroxyamide via the transfer hydrogenation of α-ketoamide
Mishra, Ashish A.,Bhanage, Bhalchandra M.
, p. 6160 - 6167 (2019/04/25)
This work reports the synthesis of α-hydroxy amide and its derivatives using zirconium-based metal-organic frameworks (Zr-MOFs). The Zr-MOF was prepared using a ligand containing different functionalities as a linker with different porosities. The catalyst efficiently facilitated the transfer hydrogenation of α-ketoamide to α-hydroxyamide. The reaction involved a green hydrogen source, namely isopropyl alcohol, which also acted as a solvent. The role of the ligand in the catalyst was optimized for the selective conversion of α-ketoamide to α-hydroxyamide. UiO-66 (Zr) crystal was efficiently used for the first time for the hydrogenation of α-ketoamide to α-hydroxyamide. The catalyst was recovered and recycled five times without any loss in activity and selectivity performance. The morphology, activity and stability of the UiO-66 (Zr) catalyst were analyzed using field emission gun scanning electron microscopy (FEG-SEM), X-ray diffraction (XRD), infra-red (IR) spectroscopy and thermogravimetric analysis (TGA). The existence of α-hydroxyamide and its derivatives was confirmed from 1H and 13C-NMR.
Α-hydroxy aryl acetylmethylene aromatic amine synthesis process
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Paragraph 0008; 0009; 0014; 0015, (2016/10/10)
Alpha-hydroxy aryl acetyl arylamine can be used as medicine and organic intermediate. The invention discloses a synthetic process of alpha-hydroxy aryl acetyl arylamine. Under existence of a copper catalyst and alkali, alpha-hydroxy aryl acetamide and ary
