10295-49-5

Basic information

• Product Name: 2-hydroxy-N-(4-methoxyphenyl)-2-phenylacetamide
• CAS NO: 10295-49-5
• Molecular Formula: C₁₅H₁₅NO₃
• Molecular Weight: 257.2845
• Mol File: 10295-49-5.mol
• Article Data: 11

Chemical Properties

• Boiling Point: 498.4°C at 760 mmHg
• Flash Point: 255.2°C
• Density: 1.252g/cm³
• Vapor Pressure: 9.39E-11mmHg at 25°C
• Refractive Index: 1.631
• CAS DataBase Reference: 2-hydroxy-N-(4-methoxyphenyl)-2-phenylacetamide(CAS DataBase Reference)
• NIST Chemistry Reference: 2-hydroxy-N-(4-methoxyphenyl)-2-phenylacetamide(10295-49-5)
• EPA Substance Registry System: 2-hydroxy-N-(4-methoxyphenyl)-2-phenylacetamide(10295-49-5)

Safety Data

• Hazardous Substances Data: 10295-49-5(Hazardous Substances Data)

Upstream product

• 104-94-9 4-methoxy-aniline 
• 611-71-2 MANDELIC ACID 
• 611-73-4 Benzoylformic acid 
• 50916-21-7 N-(4-methoxyphenyl)-2-phenylacetamide 
• 25726-04-9 phenylglyoxylyl chloride 
• 696-62-8 para-iodoanisole 
• 4410-31-5 (RS)-mandelamide 
• 39164-99-3 N-(4-methoxyphenyl)-2-oxo-2-phenylacetamide 
• 103-82-2 phenylacetic acid 

Downstream Products

• 4410-31-5 (RS)-mandelamide 
• 67824-11-7 3-(4-methoxy-phenyl)-5-phenyl-oxazolidin-4-one 

Relevant articles and documents

“On-water” reduction of α-keto amide by Hantzsch ester: A chemoselective catalyst- and additive-free way to α-hydroxy amide

An efficient and practical method for chemoselective “on-water” reduction of α-keto amide by Hantzsch ester without using any catalysts and additives was developed. Control experiments indicated that the intramolecular hydrogen bond of α-keto amide was cr

Catalyst- and Additive-Free Chemoselective Transfer Hydrogenation of α-Keto Amides to α-Hydroxy Amides by Sodium Formate

A catalyst- and additive-free chemoselective transfer hydrogenation of α-keto amides to α-hydroxy amides is easily achieved by using sodium formate as a hydrogen source. The utility of this method is demonstrated by gram-scale synthesis and transformation of the resultant α-hydroxy amides into polysubstituted acetamides and 2-arylindole derivatives. Control experiments suggest that the NH group of α-keto amides is crucial for the chemoselective reduction through the formation of hydrogen bonds.

Method for preparing alpha-hydroxy amide by selective reduction of ketone carbonyl group of alpha-ketoamide

The invention relates to a method for preparing alpha-hydroxy amide by selective reduction of a ketone carbonyl group of alpha-ketoamide. The method comprises the following steps: performing a reaction on the alpha-ketoamide and a formate in an organic so