39164-99-3

Basic information

• Product Name: N-(4-methoxyphenyl)-2-oxo-2-phenylacetamide
• Synonyms: N-(4-methoxyphenyl)-2-oxo-2-phenylacetamide
• CAS NO: 39164-99-3
• Molecular Weight: 255.273
• Mol File: 39164-99-3.mol
• Article Data: 22

Chemical Properties

• CAS DataBase Reference: N-(4-methoxyphenyl)-2-oxo-2-phenylacetamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-(4-methoxyphenyl)-2-oxo-2-phenylacetamide(39164-99-3)
• EPA Substance Registry System: N-(4-methoxyphenyl)-2-oxo-2-phenylacetamide(39164-99-3)

Safety Data

• Hazardous Substances Data: 39164-99-3(Hazardous Substances Data)

Upstream product

• 1075-06-5 2,2-dihydroxy-1-phenyl-ethanone 
• 104-94-9 4-methoxy-aniline 
• 3532-17-0 4-methoxybenzoyl azide 
• 611-73-4 Benzoylformic acid 
• 103-82-2 phenylacetic acid 
• 25726-04-9 phenylglyoxylyl chloride 
• 1516-21-8 4-methoxynitrosobenzene 
• 932-87-6 1-Bromo-2-phenylacetylene 
• 98-86-2 acetophenone 
• 103-80-0 phenylacetyl chloride 
• 50916-21-7 N-(4-methoxyphenyl)-2-phenylacetamide 
• 536-74-3 phenylacetylene 
• 100-52-7 benzaldehyde 
• 173094-32-1 3-(4-methoxyphenyl)-2-(N-methylbenzylamino)-5-phenyl-1,3-thiazolium-4-olate 

Downstream Products

• 50916-21-7 N-(4-methoxyphenyl)-2-phenylacetamide 
• 135286-06-5 (R)-2-[(4-methoxyphenyl)amino]-1-phenylethanol 

Relevant articles and documents

Rapid assembly of α-ketoamides through a decarboxylative strategy of isocyanates with α-oxocarboxylic acids under mild conditions

A simple and practical method for α-ketoamide synthesis via a decarboxylative strategy of isocyanates with α-oxocarboxylic acids is described. The reaction proceeds at room temperature under mild conditions without an oxidant or an additive, showing good substrate scope and functional compatibility. Moreover, the applicability of this method was further demonstrated by the synthesis of various bioactive molecules and different application examples through a two-step one-pot operation.

Synthetic method of alpha-keto amide compound

The invention discloses a synthesis method of an alpha-keto amide compound, which comprises the following steps: mixing a benzoyl azide compound as shown in a chemical formula I with a benzoyl formicacid compound as shown in a chemical formula II, and reacting to obtain an alpha-keto amide compound as shown in a chemical formula III; in the formula, R1 is a monosubstituted or polysubstituted group on a benzene ring; R2 is a group that is not H; the synthesis method can be used for efficiently synthesizing the functionalized alpha-ketoamide compound, has the advantages of simple synthesis steps, safety in operation, good compatibility of the synthesis method to functional groups and high atom economy, and is easy for industrial synthesis.

1,2-dicarbonyl compound and synthesis method thereof

The invention discloses a method for synthesizing a 1,2-dicarbonyl compound (1,2-dicarbonylamide or alpha-diketone compound), wherein 1,2-dicarbonyl thioester compounds used as 1,2-dicarbonyl reagentsreact with amine compounds or boric anhydride compounds under appropriate conditions to respectively synthesize a series of 1,2-dicarbonyl compounds. According to the present invention, the 1,2-dicarbonyl compound is obtained by using the stable 1,2-dicarbonyl thioester compound as the dicarbonylation reagent through one-step construction under mild conditions, such that the disadvantage that thetraditional method uses the unstable alpha-carbonyl acyl chloride to synthesize the 1,2-dicarbonyl compound is avoided.