1029580-46-8Relevant articles and documents
Silver comes into play: Henry reaction and domino cycloisomerisation sequence catalysed by [Ag(i)(Pc-L)] complexes
Tseberlidis, Giorgio,Dell'Acqua, Monica,Valcarenghi, Daniele,Gallo, Emma,Rossi, Elisabetta,Abbiati, Giorgio,Caselli, Alessandro
, p. 97404 - 97419 (2016)
We report herein the synthesis of new pyridine-containing macrocyclic ligands (Pc-L) bearing a non-innocent pendant arm, by exploiting both chiral and functional properties of natural amino acids. The obtained macrocyclic ligands were employed to synthesize well-defined cationic silver(i) complexes that were shown to be competent catalysts for the Henry (nitroaldol) reaction. Good to excellent yields and full selectivity in the β-nitroalcohol product were obtained starting from electron-poor aromatic aldehydes or other activated aldehydes such as furfural under mild reaction conditions. The straightforward synthesis of the macrocyclic ligands starting from cheap commercially available starting materials allowed the introduction of a suitable basic functionality into the ligand pendant arm, thus providing a bifunctional catalyst. Based on our previous experience in the [Ag(i)(Pc-L)] catalysed domino addition/cycloisomerisation reaction of o-alkynylbenzaldehydes and nucleophiles, the synthesis of isochromenes coupling the Henry reaction and the cycloisomerisation in a single step was subsequently explored. Although with low selectivity, [Ag(i)(Pc-L)] cationic complexes were able to promote such a cascade reaction and a possible mechanism based on experimental evidence has been proposed.
PYRAZOLE AMIDE DERIVATIVE
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Page/Page column 172, (2015/09/28)
The present invention relates to a novel compound having a function of inhibiting RORγ activity. The present invention also relates to pharmaceutical composition comprising the compound, a use of the compound in treating or preventing autoimmune diseases, inflammatory diseases, metabolic diseases, or cancer diseases.
An efficient synthesis of α-hydroxy phosphonates and 2-nitroalkanols using Ba(OH)2 as catalyst
Pandi, Muthupandi,Chanani, Prem Kumar,Govindasamy, Sekar
, p. 119 - 123 (2012/10/29)
The α-hydroxy phosphonates have been synthesized using simple, inexpensive, and commonly available Ba(OH)2·8H2O at room temperature and quantitative yields were obtained in just 15 min for most of the reactions. On applying the same reaction condition to aqueous mediated Henry reaction, 2-nitroalkanols were obtained in good to excellent yield within 15 min.
