102964-38-5Relevant academic research and scientific papers
First total synthesis of vialinin A, a novel and extremely potent inhibitor of TNF-α production
Ye, Yue Qi,Koshino, Hiroyuki,Onose, Jun-Ichi,Yoshikawa, Kunie,Abe, Naoki,Takahashi, Shunya
, p. 4131 - 4134 (2007)
Vialinin A, a powerful inhibitor (IC50 90 pM) of TNF-α production, was synthesized from sesamol in 11 steps with 28% overall yield. The key reactions include a double Suzuki coupling of electron-rich aryl triflate with phenylboronic acid and an
Structural revision of thelephantin G by total synthesis and the inhibitory activity against TNF-α production
Yue, Qi Ye,Koshino, Hiroyuki,Onose, Jun-Ichi,Negishi, Chiemi,Yoshikawa, Kunie,Abe, Naoki,Takahashi, Shunya
supporting information; experimental part, p. 4642 - 4645 (2009/09/25)
(Chemical Equation Presented) This paper describes the total synthesis of thelephantin G, thus revising the proposed structure 1 to 2. The key steps involved a double Suzuki-Miyaura coupling and an esteri-fication reaction. By a similar strategy, ganbajun
