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1029647-76-4

N-{1-[2-(4-fluorophenyl)ethyl]piperidin-3-yl}-2-methyl-2H-indazole-3-carboxamide is a chemical with a specific purpose. Lookchem provides you with multiple data and supplier information of this chemical.

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  • 1029647-76-4 Structure

  • Basic information

    1. Product Name: N-{1-[2-(4-fluorophenyl)ethyl]piperidin-3-yl}-2-methyl-2H-indazole-3-carboxamide
    2. Synonyms:
    3. CAS NO:1029647-76-4
    4. Molecular Formula:
    5. Molecular Weight: 380.465
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 1029647-76-4.mol

  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: N/A
    3. Flash Point: N/A
    4. Appearance: N/A
    5. Density: N/A
    6. Refractive Index: N/A
    7. Storage Temp.: N/A
    8. Solubility: N/A
    9. CAS DataBase Reference: N-{1-[2-(4-fluorophenyl)ethyl]piperidin-3-yl}-2-methyl-2H-indazole-3-carboxamide(CAS DataBase Reference)
    10. NIST Chemistry Reference: N-{1-[2-(4-fluorophenyl)ethyl]piperidin-3-yl}-2-methyl-2H-indazole-3-carboxamide(1029647-76-4)
    11. EPA Substance Registry System: N-{1-[2-(4-fluorophenyl)ethyl]piperidin-3-yl}-2-methyl-2H-indazole-3-carboxamide(1029647-76-4)

  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 1029647-76-4(Hazardous Substances Data)

1029647-76-4 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 1029647-76-4 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,0,2,9,6,4 and 7 respectively; the second part has 2 digits, 7 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 1029647-76:
(9*1)+(8*0)+(7*2)+(6*9)+(5*6)+(4*4)+(3*7)+(2*7)+(1*6)=164
164 % 10 = 4
So 1029647-76-4 is a valid CAS Registry Number.

1029647-76-4Downstream Products

1029647-76-4Relevant articles and documents

Targeting Serotonin 2A and Adrenergic α1 Receptors for Ocular Antihypertensive Agents: Discovery of 3,4-Dihydropyrazino[1,2-b]indazol-1(2H)-one Derivatives

Furlotti, Guido,Alisi, Maria Alessandra,Cazzolla, Nicola,Ceccacci, Francesca,Garrone, Beatrice,Gasperi, Tecla,La Bella, Angela,Leonelli, Francesca,Loreto, Maria Antonietta,Magarò, Gabriele,Mangano, Giorgina,Bettolo, Rinaldo Marini,Masini, Emanuela,Miceli, Martina,Migneco, Luisa Maria,Vitiello, Marco

, p. 1597 - 1607 (2018/07/30)

Glaucoma affects millions of people worldwide and causes optic nerve damage and blindness. The elevation of the intraocular pressure (IOP) is the main risk factor associated with this pathology, and decreasing IOP is the key therapeutic target of current pharmacological treatments. As potential ocular hypotensive agents, we studied compounds that act on two receptors (serotonin 2A and adrenergic α1) linked to the regulation of aqueous humour dynamics. Herein we describe the design, synthesis, and pharmacological profiling of a series of novel bicyclic and tricyclic N2-alkyl-indazole-amide derivatives. This study identified a 3,4-dihydropyrazino[1,2-b]indazol-1(2H)-one derivative with potent serotonin 2A receptor antagonism, >100-fold selectivity over other serotonin subtype receptors, and high affinity for the α1 receptor. Moreover, upon local administration, this compound showed superior ocular hypotensive action in vivo relative to the clinically used reference compound timolol.

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