34252-44-3

Basic information

• Product Name: 2-METHYL-2H-INDAZOLE-3-CARBOXYLIC ACID
• Synonyms: 2-METHYL-2H-INDAZOLE-3-CARBOXYLIC ACID;2-Methylindazole-3-carboxylic acid;2H-Indazole-3-carboxylic acid,2-methyl-;3-Carboxy-2-methyl-2H-indazole;2-Methylindazole-3-carboxylic acid 2-Methyl-2H-indazole-3-carboxylic acid;2-Methyl-2H-indazole-3-carboxylicacid97%;Granisetron EP impurity G;2-Methylindazole-3-carboxylic acid 2-Methyl-2H-indazole
• CAS NO: 34252-44-3
• Molecular Formula: C₉H₈N₂O₂
• Molecular Weight: 176.17
• EINECS: 1533716-785-6
• Product Categories: Chemical Amines;Amines;Aromatics;Heterocycles
• Mol File: 34252-44-3.mol
• Article Data: 4

Chemical Properties

• Melting Point: 217-219
• Boiling Point: 417.4 °C at 760 mmHg
• Flash Point: 206.2 °C
• Appearance: white solid
• Density: 1.35
• Vapor Pressure: 1.03E-07mmHg at 25°C
• Refractive Index: 1.653
• Storage Temp.: Refrigerator
• Solubility: DMSO (Slightly), Methanol (Slightly)
• PKA: 3.02±0.10(Predicted)
• CAS DataBase Reference: 2-METHYL-2H-INDAZOLE-3-CARBOXYLIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: 2-METHYL-2H-INDAZOLE-3-CARBOXYLIC ACID(34252-44-3)
• EPA Substance Registry System: 2-METHYL-2H-INDAZOLE-3-CARBOXYLIC ACID(34252-44-3)

Safety Data

• Hazard Codes: Xn
• Statements: 22-36-36/37/38-20/21/22
• Safety Statements: 26-36/37/39-22
• RIDADR: 2811
• Hazardous Substances Data: 34252-44-3(Hazardous Substances Data)

Usage

Chemical Properties

White Solid

Uses

2-Methyl-2H-indazole-3-carboxylic acid can be used as a reagent used to synthesize 5-HT2A and 5-HT3 receptor ligands for use in treating CNS-related disorders.

InChI:InChI=1/C9H8N2O2/c1-11-8(9(12)13)6-4-2-3-5-7(6)10-11/h2-5H,1H3,(H,12,13)

Upstream product

• 74-88-4 methyl iodide 
• 4498-68-4 ethyl 1H-indazole-3-carboxylate 
• 4498-67-3 1H-Indazole-3-carboxylic acid 
• 109216-61-7 3-methoxycarbonyl-2-methylisoindazole 
• 43120-28-1 methyl 1H-indazole-3-carboxylate 
• 77-78-1 dimethyl sulfate 
• 186581-53-3 diazomethane 
• 50264-88-5 indazole-3-carbonitrile 
• 31748-45-5 2-methyl-2H-indazole-3-carbonitrile 

Downstream Products

• 1029647-73-1 N-{1-[2-(4-fluorophenyl)ethyl]pyrrolidin-3-yl}-2-methyl-2H-indazole-3-carboxamide 
• 1029647-76-4 N-{1-[2-(4-fluorophenyl)ethyl]piperidin-3-yl}-2-methyl-2H-indazole-3-carboxamide 
• 1029643-75-1 N-{3-[4-(4-fluorophenyl)piperidin-1-yl]propyl}-2-methyl-2H-indazole-3-carboxamide 
• 1029643-74-0 N-{2-[4-(4-fluorophenyl)piperidin-1-yl]ethyl}-2-methyl-2H-indazole-3-carboxamide 
• 1029643-77-3 N-{1-[3-(4-fluorophenyl)propyl]piperidin-4-yl}-2-methyl-2H-indazole-3- carboxamide 
• 1029643-76-2 N-(1-benzylpiperidin-4-yl)-2-methyl-2H-indazole-3-carboxamide 
• 1029643-73-9 N-{1-(2-(2-fluorophenyl)ethyl)piperidin-4-yl}-2-methyl-2H-indazole-3-carboxamide 
• 1029643-78-4 N-({1-[2-(2,4-difluorophenyl)ethyl]piperidin-4-yl}methyl)-2-methyl-2H-indazole-3-carboxamide 
• 1029643-72-8 2-methyl-N-[(1-{2-[4-(trifluoromethyl)phenyl]ethyl}piperidin-4-yl)methyl]-2H-indazole-3-carboxamide 
• 1029643-68-2 N-({1-[2-(2-fluorophenyl)ethyl]piperidin-4-yl}methyl)-2-methyl-2H-indazole-3-carboxamide 
• 1029643-59-1 3N-({1-[2-(4-hydroxyphenyl)ethyl]hexahydro-4-pyridinyl}methyl)-2-methyl-2H-3-indazolecarboxamide hydrochloride 
• 441715-65-7 ethyl (5-chloro-2-fluoro-4-((2-methyl-3-indazolylcarbonyl)amino)phenyl)acetate 
• 127472-42-8 endo-N-(9-methyl-9-azabicyclo<3.3.1>nonan-3-yl)-2-methyl-2H-indazole-3-carboxamide 
• 181071-92-1 2-methyl-2H-indazole-3-carbonyl chloride 

Relevant articles and documents

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2 -ALKYL- INDAZOLE COMPOUNDS FOR THE TREATMENT OF CERTAIN CNS-RELATED DISORDERS

2-Alkyl-indazole compound and its pharmaceutically acceptable salts of acid addition, method and intermediates for preparing them, a pharmaceutical composition containing them and use of the latter. The 2-alkyl-indazole compound has the following general formula (I) in which R1, R2, R3, R4, R6, R7, X, Y, W, n, p, and m have the meanings stated in the description.

Indazoles as indole bioisosteres: Synthesis and evaluation of the tropanyl ester and amide of indazole-3-carboxylate as antagonists at the serotonin 5HT3 receptor

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