1029697-07-1Relevant academic research and scientific papers
A Unified Approach to Customized Chiral Carbon-Bridged ansa-Metallocenes
Wiesler, Stefan,Bau, Michael A.,Younas, Sara L.,Luu, Hieu-Trinh,Kratzert, Daniel,Streuff, Jan
, p. 16532 - 16536 (2018)
Chiral ansa-metallocenes are privileged catalysts for a range of stereoselective transformations. Their synthesis, however, has remained a tremendous challenge, which has prevented a broad and systematic exploration for applications in synthesis and catalysis. A modular approach to such ansa-metallocenes that enables a facile modification of the ring substitution and the ligand bridge, as well as the introduction of various core metals, is described. The complexes were formed with good rac-selectivity and could be isolated with high purity. The strength of the approach was demonstrated by the synthesis of several new and previously known complexes, including a unique helical chiral ansa-metallocene. Using a chiral ligand, a moderate central-to-planar chirality transfer was observed.
Synthesis of α,ω-Bis-Enones by the Double Addition of Alkenyl Grignard Reagents to Diacid Weinreb Amides
Wiesler, Stefan,Bau, Michael A.,Niepel, Thomas,Younas, Sara L.,Luu, Hieu-Trinh,Streuff, Jan
, p. 6246 - 6260 (2019/09/10)
An efficient double addition of substituted alkenylmagnesium bromides to bis-Weinreb amides has been developed, giving α,ω-bis-enones that are building blocks for certain drugs and polymers. Furthermore, reliable protocols for the preparation of the requi
DICARBONYL DERIVATIVES AND METHODS OF USE
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Page/Page column 35, (2008/12/05)
Derivatives of dicarbonyl compounds having antitumor and antibiotic activity which can be used as anticancer agents.
