1029797-95-2Relevant academic research and scientific papers
Novel protein kinase inhibitors related to tau pathology modulate tau protein-self interaction using a luciferase complementation assay
Holzer, Max,Schade, Nico,Opitz, Ansgar,Hilbrich, Isabel,Stieler, Jens,Vogel, Tim,Neukel, Valentina,Oberstadt, Moritz,Totzke, Frank,Schchtele, Christoph,Sippl, Wolfgang,Hilgeroth, Andreas
, (2018/09/26)
The current number of drugs available for the treatment of Alzheimer's disease (AD) is strongly limited and their benefit for therapy is given only in the early state of the disease. An effective therapy should affect those processes which mainly contribu
First biological evaluation of developed 3-benzyloxyfluorenes as novel class of MDR modulators
Krug, Martin,Voigt, Burkhardt,Baumert, Christiane,Lüpken, Ralf,Molnár, Joséf,Hilgeroth, Andreas
experimental part, p. 2683 - 2688 (2010/07/09)
A series of 3-benzyloxy-1-aza-9-oxafluorenes has been synthesized and biologically evaluated as novel MDR modulators. The concentration dependent inhibition of the efflux pump ABCB1 (P-glycoprotein) has been characterized and is discussed in relation to calculated lipophilicity data. Instead of the molecular lipophilicity the exact positioning of functional groups was found decisive for the biological activities.
