102993-38-4

Basic information

• Product Name: Butanoic acid, 2-[(3-nitrophenyl)methylene]-3-oxo-, 2-cyanoethyl ester
• CAS NO: 102993-38-4
• Molecular Formula: C14H12N2O5
• Molecular Weight: 288.26
• Mol File: 102993-38-4.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: Butanoic acid, 2-[(3-nitrophenyl)methylene]-3-oxo-, 2-cyanoethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: Butanoic acid, 2-[(3-nitrophenyl)methylene]-3-oxo-, 2-cyanoethyl ester(102993-38-4)
• EPA Substance Registry System: Butanoic acid, 2-[(3-nitrophenyl)methylene]-3-oxo-, 2-cyanoethyl ester(102993-38-4)

Safety Data

• Hazardous Substances Data: 102993-38-4(Hazardous Substances Data)

Upstream product

• 99-61-6 3-nitro-benzaldehyde 
• 65193-87-5 2-cyanoethylacetoacetate 

Downstream Products

• 74936-72-4 5-methoxycarbonyl-2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3-carboxylic acid 
• 76093-33-9 (R)-5-(methoxycarbonyl)-2,6-dimethyl-4-(m-nitrophenyl)-1,4-dihydropyridine-3-carboxylic acid 
• 104713-75-9 barnidipine 
• 172331-68-9 3-(R)-1-benzylpyrrolidin-3-yl 5-methyl 2,6-dimethyl-4-(3-nitrophenyl)pyridine-3,5-dicarboxylate 
• 88712-56-5 methyl (R)-5-chlorocarbonyl-2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3-carboxylate 
• 80873-62-7 (-)-Nitrendipine 
• 88712-56-5 1,4-dihydro-2,6-dimethyl-3-methoxycarbonyl-4-(3-nitrophenyl)-pyridine-5-carboxylic acid chloride 
• 104757-53-1 [14C]-Barnidipine hydrochloride 
• 74936-73-5 5-(ethoxycarbonyl)-2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3-carboxylic acid 
• 439694-61-8 (R)-5-(ethoxycarbonyl)-2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3-carboxylic acid 
• 75130-24-4 2,6-dimethyl-4-(3-nitrophenyl)-5-methoxycarbonyl-1,4-dihydropyridine-3-carboxylic acid 2-cyanoethyl ester 
• 75130-25-5 3-(2-cyanoethyl) 5-ethyl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate 
• 76093-34-0 (+)-(S)-1,4-dihydro-2,6-dimethyl-5-methoxycarbonyl-4-(3-nitrophenyl)pyridine-3-carboxylic acid 

Relevant articles and documents

Synthesis and characterization of impurities of barnidipine hydrochloride, an antihypertensive drug substance

Barnidipine hydrochloride is a long term dihydropyridine calcium channel blocker used for the treatment of hypertension. During the process development of barnidipine hydrochloride, four barnidipine impurities were detected by high-performance liquid chromatography (HPLC) with an ordinary column (Agilent ZORBAX Eclipse XDB-C18, 150 mm × 4.6 mm, 5 m). All these impurities were identified, synthesized, and subsequently characterized by their respective spectral data (MS, 1H-NMR, and 13C-NMR). The identification of these impurities should be useful for quality control in the manufacture of barnidipine.