Molecules p. 1344 - 1352 (2014)
Update date:2022-08-05
Topics:
Cheng, Zhi-Gang
Dai, Xu-Yong
Li, Li-Wei
Wan, Qiong
Ma, Xiang
Xiang, Guang-Ya
Barnidipine hydrochloride is a long term dihydropyridine calcium channel blocker used for the treatment of hypertension. During the process development of barnidipine hydrochloride, four barnidipine impurities were detected by high-performance liquid chromatography (HPLC) with an ordinary column (Agilent ZORBAX Eclipse XDB-C18, 150 mm × 4.6 mm, 5 m). All these impurities were identified, synthesized, and subsequently characterized by their respective spectral data (MS, 1H-NMR, and 13C-NMR). The identification of these impurities should be useful for quality control in the manufacture of barnidipine.
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