1030377-24-2

Basic information

• Product Name: 1-benzyl 4-tert-butyl 5-methyl-1,4-diazepane-1,4-dicarboxylate
• Synonyms: 1-benzyl 4-tert-butyl 5-methyl-1,4-diazepane-1,4-dicarboxylate
• CAS NO: 1030377-24-2
• Molecular Weight: 348.442
• Mol File: 1030377-24-2.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 1-benzyl 4-tert-butyl 5-methyl-1,4-diazepane-1,4-dicarboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: 1-benzyl 4-tert-butyl 5-methyl-1,4-diazepane-1,4-dicarboxylate(1030377-24-2)
• EPA Substance Registry System: 1-benzyl 4-tert-butyl 5-methyl-1,4-diazepane-1,4-dicarboxylate(1030377-24-2)

Safety Data

• Hazardous Substances Data: 1030377-24-2(Hazardous Substances Data)

Usage

Chemical class

Diazepanes

Structural similarity

Benzodiazepines

Derivative of

Diazepam

Properties

Sedative and anxiolytic

Use

Central nervous system depressant

Mechanism of action

Enhances the effects of gamma-aminobutyric acid (GABA) in the brain

Pharmacological activity

Influenced by benzyl and tert-butyl groups

Solubility and stability

Enhanced by carboxylate groups

Application

Research and potential therapeutic uses

Receptor modulation

GABA receptors in the brain

Upstream product

• 57260-73-8 N-BOC-1,2-diaminoethane 
• 24424-99-5 di-tert-butyl dicarbonate 
• 1030377-23-1 benzyl (2-((tert-butoxycarbonyl)amino)ethyl)(3-oxobutanoyl)carbamate 
• 217972-87-7 benzyl 5-methyl-1,4-diazepane-1-carboxylate 

Downstream Products

• 1030377-25-3 1-benzyl 4-tert-butyl (5R)-5-methyl-1,4-diazepane-1,4-dicarboxylate 
• 1030377-26-4 1-benzyl 4-tert-butyl (5S)-5-methyl-1,4-diazepane-1,4-dicarboxylate 
• 1352834-53-7 (rac)-benzyl 5-methyl-1,4-diazepane-1-carboxylate hydrochloride 
• 1352834-54-8 benzyl 5-methyl-4-(5-methyl-2-(2H-1,2,3-triazole-2-yl)benzoyl)-1,4-diazepane-1-carboxylate 
• 1001401-59-7 (7-methyl-1,4-diazepan-1-yl)(5-methyl-2-(2H-1,2,3-triazol-2-yl)phenyl)methanone 
• 1352834-55-9 (4-(5-chlorobenzoxazol-2-yl)-7-methyl-1,4-diazepan-1-yl)(5-methyl-2-(2H-1,2,3-triazol-2-yl)phenyl)methanone 

Relevant articles and documents

Amination of benzoxazoles and 1,3,4-oxadiazoles using 2,2,6,6- tetramethylpiperidine-N-oxoammonium tetrafluoroborate as an organic oxidant

No transition metals are necessary to convert benzoxazoles and 1,3,4-oxadiazoles into the corresponding pharmacologically interesting 2-aminated heterocycles by formal direct C(2)-amination using tetramethylpiperidine-N-oxoammonium tetrafluoroborate (TEMPO+BF 4-) as an oxidant (see scheme; TEMP=2,2,6,6- tetramethylpiperidine; TfOH=trifluoromethanesulfonic acid).

Substituted diazepan orexin receptor antagonists

The present invention is directed to substituted diazepan compounds which are antagonists of orexin receptors, and which are useful in the treatment or prevention of neurological and psychiatric disorders and diseases in which orexin receptors are involved. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which orexin receptors are involved.