103041-75-4

Upstream product

• 2199-47-5 ethyl 3,5-dimethyl-4-ethylpyrrole-2-carboxylate 
• 1925-61-7 benzyl 4-ethyl-3,5-dimethylpyrrole-2-carboxylate 

Downstream Products

• 103046-94-2 4-ethyl-5-(4-dimethylamino-benzyl)-3-methyl-pyrrole-2-carboxylic acid benzyl ester 
• 448-71-5 ethioporphyrin I 
• 114402-63-0 4-ethyl-5-benzyloximethyl-3-methyl-pyrrole-2-carboxylic acid benzyl ester 
• 47367-49-7 5-diethylaminomethyl-4-ethyl-3-methyl-pyrrole-2-carboxylic acid benzyl ester 
• 965-20-8 4-Ethyl-5-formyl-3-methyl-1H-pyrrol-2-carbonsaeure-benzylester 
• 115097-60-4 5-(4-ethoxycarbonyl-3,5-dimethyl-pyrrol-2-ylmethyl)-4-ethyl-3-methyl-pyrrole-2-carboxylic acid benzyl ester 
• 108975-62-8 benzyl 4-ethyl-5-methoxymethyl-3-methylpyrrole-2-carboxylate 

Relevant academic research and scientific papers

Syntheses of type-I porphyrins via monopyrrole tetramerization

Treatment of 2-[(N,N-dialkylamino)methyl]pyrrole-5-carboxylic acids (e.g. 10,12 or 11,13) in methanol with K3Fe(CN)6 gives type-I porphyrins (etioporphyrin-I 7, coproporphyrin-I tetramethyl ester 16, respectively); with pyrroles 10,12 the product 7 is contaminated with about 8% of other type-isomer(s).

REACTION ON SOLID SUPPORT PART V: THE MECHANISM OF OXIDATION OF α-METHYLPYRROLES TO α-FORMYLPYRROLES BY TALLIUM NITRATE ON CLAY

Evidence is presented to show that the clay-catalyzed thallium nitrate oxidation of α-methylpyrroles to α-formylpyrroles involves formation of an intermediate nitrate ester which subsequently undergoes elimination of nitrite.