1030471-15-8

Basic information

• Product Name: p-tert-butyl-α,α,α-trifluoromethoxybenzene
• Synonyms: p-tert-butyl-α,α,α-trifluoromethoxybenzene
• CAS NO: 1030471-15-8
• Molecular Weight: 218.219
• Mol File: 1030471-15-8.mol
• Article Data: 15

Chemical Properties

• CAS DataBase Reference: p-tert-butyl-α,α,α-trifluoromethoxybenzene(CAS DataBase Reference)
• NIST Chemistry Reference: p-tert-butyl-α,α,α-trifluoromethoxybenzene(1030471-15-8)
• EPA Substance Registry System: p-tert-butyl-α,α,α-trifluoromethoxybenzene(1030471-15-8)

Safety Data

• Hazardous Substances Data: 1030471-15-8(Hazardous Substances Data)

Upstream product

• 507-19-7 t-butyl bromide 
• 456-55-3 1-trifluoromethoxybenzene 
• 17688-83-4 2,5-tert-butyl-4-methyl-phenol 
• 461-81-4 1-chloro-4-(trifluoromethoxy)benzene 
• 106-48-9 4-chloro-phenol 
• 75-15-0 carbon disulfide 
• 98-54-4 para-tert-butylphenol 
• 953091-35-5 ethyl 2-[4-(tert-butyl)phenoxy]-2,2-difluoroacetate 
• 953090-88-5 2-fluoro-2-(4-(trifluoromethyl)phenoxy)acetic acid 
• 1435486-09-1 ethyl (4-tert-butylphenoxy)(fluoro)acetate 
• 1035797-66-0 benzoic acid trifluoromethyl ester 
• 253185-03-4 tert-butylbenzene 
• 407-14-7 1-bromo-4-(trifluoromethoxy)benzene 
• 677-22-5 tert-butylmagnesium chloride 

Downstream Products

• 18412-68-5 (4-tert-butylphenyl)trimethylsilane 

Relevant articles and documents

Fluorodecarboxylation for the Synthesis of Trifluoromethyl Aryl Ethers

The synthesis of mono-, di-, and trifluoromethyl aryl ethers by fluorodecarboxylation of the corresponding carboxylic acids is reported. AgF2induces decarboxylation of aryloxydifluoroacetic acids, and AgF, either generated in situ or added separately, serves as a source of fluorine to generate the fluorodecarboxylation products. The addition of 2,6-difluoropyridine increased the reactivity of AgF2, thereby increasing the range of functional groups and electronic properties of the aryl groups that are tolerated. The reaction conditions used for the formation of trifluoromethyl aryl ethers also served to form difluoromethyl and monofluoromethyl aryl ethers.

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ALPHAvBETA1 INTEGRIN ANTAGONISTS

The present disclosure provides pharmaceutical agents, including those of the formula: (I) wherein the variables are defined herein. Also provided are pharmaceutical compositions, kits and articles of manufacture comprising such pharmaceutical agents. Methods of using the pharmaceutical agents are also provided. The compounds may be used for the inhibition or antagonism of integrins ανβ1 and/or α5β1. In some embodiments, the compounds provided herein exhibit reduced inhibitory or antagonistic activity of integrins ανβ3, ανβ5, ανβ6, ανβ8, and/or αIIbβ3.

Generation of Alkyl Radical through Direct Excitation of Boracene-Based Alkylborate

The generation of tertiary, secondary, and primary alkyl radicals has been achieved by the direct visible-light excitation of a boracene-based alkylborate. This system is based on the photophysical properties of the organoboron molecule. The protocol is applicable to decyanoalkylation, Giese addition, and nickel-catalyzed carbon-carbon bond formations such as alkyl-aryl cross-coupling or vicinal alkylarylation of alkenes, enabling the introduction of various C(sp3) fragments to organic molecules.