103057-10-9

Basic information

• Product Name: 4-(CHLOROMETHYL)-1-TRITYL-1H-IMIDAZOLE
• Synonyms: 4-(CHLOROMETHYL)-1-TRITYL-1H-IMIDAZOLE;4-(chloromethyl)-1-(triphenylmethyl)-1H-Imidazole
• CAS NO: 103057-10-9
• Molecular Formula: C₂₃H₁₉ClN₂
• Molecular Weight: 358.86
• Mol File: 103057-10-9.mol
• Article Data: 11

Chemical Properties

• Melting Point: 139-141 °C
• Boiling Point: 503.4°C at 760 mmHg
• Flash Point: 258.3°C
• Appearance: /
• Density: 1.12g/cm³
• Vapor Pressure: 9.08E-10mmHg at 25°C
• Refractive Index: 1.609
• Storage Temp.: Inert atmosphere,Room Temperature
• PKA: 5.28±0.70(Predicted)
• CAS DataBase Reference: 4-(CHLOROMETHYL)-1-TRITYL-1H-IMIDAZOLE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(CHLOROMETHYL)-1-TRITYL-1H-IMIDAZOLE(103057-10-9)
• EPA Substance Registry System: 4-(CHLOROMETHYL)-1-TRITYL-1H-IMIDAZOLE(103057-10-9)

Safety Data

• Hazard Codes: Xi
• Statements: 41
• Safety Statements: 26-39
• Hazardous Substances Data: 103057-10-9(Hazardous Substances Data)

Usage

General Description

4-(Chloromethyl)-1-trityl-1H-imidazole is a chemical compound that belongs to the class of organic compounds known as trityls. These compounds contain a trityl moiety, which consists of a phenyl group substituted with three methyl groups. Specifically, in 4-(chloromethyl)-1-trityl-1H-imidazole, a trityl group is connected to an imidazole ring, which is a five-membered ring with two nitrogen atoms. The chloromethyl group is connected to the imidazole ring as well. The presence of chloromethyl group imparts reactivity to the compound, making it a valuable compound in chemical synthesis processes. Like many organic compounds, it is typically used in laboratory settings and is handled following safety procedures due to its reactivity and potential toxicity.

InChI:InChI=1/C23H19ClN2/c24-16-22-17-26(18-25-22)23(19-10-4-1-5-11-19,20-12-6-2-7-13-20)21-14-8-3-9-15-21/h1-15,17-18H,16H2

Upstream product

• 76-83-5 trityl chloride 
• 33769-07-2 4-(hydroxymethyl)-1-(triphenylmethyl)imidazole 

Downstream Products

• 122027-50-3 4-<2-phenyl-2-(4-pyridinyl)ethyl>-1-tritylimidazole 
• 122027-52-5 2-[1-Phenyl-2-(1-trityl-1H-imidazol-4-yl)-ethyl]-pyridine 
• 473659-21-1 diethyl (1-tritylimidazol-4-yl)methylphosphonate 
• 5570-77-4 4-chloro-1-methylpiperidine 
• 500783-13-1 C₄₂H₄₅N₅O₄ 
• 500782-77-4 C₃₄H₃₂N₄O 
• 397867-86-6 methyl N-benzoyl-N-[piperidin-4-yl-N-(tritylimidazol-4-ylmethyl)]-(S)-methioninate 
• 543697-39-8 3-{2-[(2S,3R,4R,5S,6S)-6-(5-Azido-pentyloxymethyl)-4-benzyloxy-5-(4-methoxy-benzyloxy)-3-(1-trityl-1H-imidazol-4-ylmethoxy)-tetrahydro-pyran-2-yloxy]-ethyl}-1-benzenesulfonyl-1H-indole 
• 331992-77-9 4-[(1,2,3,4-tetrahydronaphthalen-1-on-2-yl)methyl]-1-tritylimidazole 

Relevant articles and documents

Targeting GRP receptor: Design, synthesis and preliminary biological characterization of new non-peptide antagonists of bombesin

We report the rational design, synthesis, and in vitro preliminary evaluation of a new small library of non-peptide ligands of Gastrin Releasing Peptide Receptor (GRP-R), able to antagonize its natural ligand bombesin (BN) in the nanomolar range of concen

HETEROARYL RHEB INHIBITORS AND USES THEREOF

The present invention provides compounds, compositions thereof, and methods of using the same. Compositions comprising a compound of this invention or a pharmaceutically acceptable derivative thereof and a pharmaceutically acceptable carrier, adjuvant, or vehicle. The amount of the compound in compositions of this invention is such that it is effective to measurably inhibit Rheb, in a biological sample or in a patient.

Synthesis and evaluation of potent, highly-selective, 3-aryl-piperazinone inhibitors of protein geranylgeranyltransferase-I

A series of compounds based on the carboxyl-terminal CAAL sequence of PGGTase-I substrates was designed and synthesized. Using piperazin-2-one as a semi-rigid scaffold, we have introduced critical pharmacophores in a well-defined arrangement to mimic the CAAL sequence. High potency and exceptional selectivity were obtained for inhibition of PGGTase-I with structures such as 45 and 70. Potency of this series of GGTIs was dependent on the presence of an l-leucine residue with a free carboxyl terminus, as well as an S configuration of the 3-aryl group. The selectivity was significantly enhanced by 5-methyl substitution on the imidazole ring and fluorine substitution on the 3-aryl group. Modification of the 6-position of the piperazinone scaffold was found to be unfavorable. Compounds 44 and 69, the corresponding methyl esters of 45 and 70, were found to selectively block processing of Rap1A by PGGTase-I in whole cells with IC50 values of 0.4 M and 0.7 M respectively. The Royal Society of Chemistry 2006.