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1-TRITYL-1H-IMIDAZOLE-4-METHANOL is a chemical compound that belongs to the class of imidazole derivatives. It is recognized for its versatility in organic synthesis and pharmaceutical research, serving as a building block for the synthesis of various drugs and bioactive molecules. Its ability to facilitate the formation of carbon-carbon and carbon-nitrogen bonds makes it a valuable reagent in the production of complex organic compounds. Furthermore, 1-TRITYL-1H-IMIDAZOLE-4-METHANOL has garnered interest for its potential therapeutic applications in the treatment of various diseases and disorders, underscoring its importance in medicinal chemistry.

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  • 33769-07-2 Structure
  • Basic information

    1. Product Name: 1-TRITYL-1H-IMIDAZOLE-4-METHANOL
    2. Synonyms: RARECHEM AL BD 0931;4-HYDROXYMETHYL-1H-TRITYLIMIDAZOLE;1-TRITYL-IMIDOZOLE-4-METHANOL;1-TRITYL-1H-IMIDAZOLE-4-METHANOL;(1-TRITYL-1H-IMIDAZOL-4-YL)-METHANOL;4-(Hydroxymethyl)-1-trityl-1H-imidazole;1-(Triphenylmethyl)-4-(hydroxymethyl)imidazole;1-Triphenylmethyl-1H-imidazole-4-methanol
    3. CAS NO:33769-07-2
    4. Molecular Formula: C23H20N2O
    5. Molecular Weight: 340.42
    6. EINECS: N/A
    7. Product Categories: blocks;Imidazoles
    8. Mol File: 33769-07-2.mol
  • Chemical Properties

    1. Melting Point: 226-232
    2. Boiling Point: 516.1 °C at 760 mmHg
    3. Flash Point: 265.9 °C
    4. Appearance: /
    5. Density: 1.1 g/cm3
    6. Vapor Pressure: 1.77E-11mmHg at 25°C
    7. Refractive Index: 1.612
    8. Storage Temp.: N/A
    9. Solubility: N/A
    10. PKA: 13.61±0.10(Predicted)
    11. CAS DataBase Reference: 1-TRITYL-1H-IMIDAZOLE-4-METHANOL(CAS DataBase Reference)
    12. NIST Chemistry Reference: 1-TRITYL-1H-IMIDAZOLE-4-METHANOL(33769-07-2)
    13. EPA Substance Registry System: 1-TRITYL-1H-IMIDAZOLE-4-METHANOL(33769-07-2)
  • Safety Data

    1. Hazard Codes: Xi
    2. Statements: 36/37/38
    3. Safety Statements: 26-36/37/39
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 33769-07-2(Hazardous Substances Data)

33769-07-2 Usage

Uses

Used in Organic Synthesis:
1-TRITYL-1H-IMIDAZOLE-4-METHANOL is used as a building block for the synthesis of various drugs and bioactive molecules, due to its capacity to form carbon-carbon and carbon-nitrogen bonds, which are essential in creating complex organic compounds.
Used in Pharmaceutical Research:
In the pharmaceutical industry, 1-TRITYL-1H-IMIDAZOLE-4-METHANOL is utilized as a versatile reagent for the development of new drugs, given its role in the formation of crucial chemical bonds that are integral to the structure and function of many pharmaceutical agents.
Used in Medicinal Chemistry:
1-TRITYL-1H-IMIDAZOLE-4-METHANOL is studied for its potential therapeutic applications in the treatment of various diseases and disorders, highlighting its significance in advancing the discovery and design of novel therapeutic agents.

Check Digit Verification of cas no

The CAS Registry Mumber 33769-07-2 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 3,3,7,6 and 9 respectively; the second part has 2 digits, 0 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 33769-07:
(7*3)+(6*3)+(5*7)+(4*6)+(3*9)+(2*0)+(1*7)=132
132 % 10 = 2
So 33769-07-2 is a valid CAS Registry Number.
InChI:InChI=1/C23H20N2O/c26-17-22-16-25(18-24-22)23(19-10-4-1-5-11-19,20-12-6-2-7-13-20)21-14-8-3-9-15-21/h1-16,18,26H,17H2

33769-07-2SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 19, 2017

Revision Date: Aug 19, 2017

1.Identification

1.1 GHS Product identifier

Product name 1-Trityl-1H-imidazole-4-methanol

1.2 Other means of identification

Product number -
Other names (1-tritylimidazol-4-yl)methanol

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:33769-07-2 SDS

33769-07-2Relevant articles and documents

Targeting GRP receptor: Design, synthesis and preliminary biological characterization of new non-peptide antagonists of bombesin

Palmioli, Alessandro,Nicolini, Gabriella,Tripodi, Farida,Orsato, Alexandre,Ceresa, Cecilia,Donzelli, Elisabetta,Arici, Martina,Coccetti, Paola,Rocchetti, Marcella,La Ferla, Barbara,Airoldi, Cristina

supporting information, (2021/02/27)

We report the rational design, synthesis, and in vitro preliminary evaluation of a new small library of non-peptide ligands of Gastrin Releasing Peptide Receptor (GRP-R), able to antagonize its natural ligand bombesin (BN) in the nanomolar range of concen

ANDROGEN RECEPTOR MODULATORS AND METHODS FOR THEIR USE

-

Paragraph 0968; 0969, (2020/05/06)

The present invention relates to compounds of formula (I)-(VI) and/or (A)-(H-I), or any subgenera thereof, or a pharmaceutically acceptable salt, tautomer or stereoisomer. The compounds of the present disclosure are useful in modulating androgen receptor activity and for treating cancer including prostate cancer.

HETEROARYL RHEB INHIBITORS AND USES THEREOF

-

Paragraph 00401, (2018/11/10)

The present invention provides compounds, compositions thereof, and methods of using the same. Compositions comprising a compound of this invention or a pharmaceutically acceptable derivative thereof and a pharmaceutically acceptable carrier, adjuvant, or vehicle. The amount of the compound in compositions of this invention is such that it is effective to measurably inhibit Rheb, in a biological sample or in a patient.

Synthesis and antiproliferatory activity of ruthenium complexes containing N-heterocyclic carboxylates

Kennedy, David C.,James, Brian R.

, p. 32 - 36 (2017/03/11)

Solvates of the complexes Ru2Cl(pic)4(EtOH) (2), Ru(Im-CO2)3 (3), and Ru(Im-CO2)(Im-CO2H)Cl2 (4), were synthesized from reaction of RuCl3·3H2O or K3[RuCl6] with the N-heterocyclic carboxylic acids pyridine-2-carboxylic acid (picolinic acid, Hpic), and imidazole-4-carboxylic acid (Im-CO2H). Crystals of 2–4 could not be grown and hence characterization was done by elemental analysis, NMR, IR, and conductivity data; 2 and 4 were tested for antiproliferatory activity in vitro against a human breast cancer cell line, but were less active than, for example, Ru complexes containing bis-imidazole or 4,4′-biimidazole that we studied previously [see Can. J. Chem. 89 (2011) 948]. Preliminary work with a third potential ligand, 3-nitro-1,2,4-triazole-5-carboxylic acid (abbreviated HCANT), and other nitro heterocyclic compounds is also presented.

BICYCLIC LACTAMS AND METHODS OF USE THEREOF

-

Page/Page column 132, (2017/01/23)

The invention provides novel compounds having the general formula I: (I) wherein R1, X, Z1, L, n, the A ring, the B ring, and the C ring are as described herein, pharmaceutical compositions including the compounds and methods of using the compounds.

Synthesis method of calmodulin inhibitor for treating brain-derived diseases

-

Paragraph 0033; 0034; 0035, (2017/08/29)

The invention discloses a synthesis method of a calmodulin inhibitor for treating brain-derived diseases and belongs to the technical field of synthesis of chemicals. The technical scheme is characterized in that a synthetic route of the synthesis method

Structure-Activity Relationships, Pharmacokinetics, and in Vivo Activity of CYP11B2 and CYP11B1 Inhibitors

Papillon, Julien P. N.,Adams, Christopher M.,Hu, Qi-Ying,Lou, Changgang,Singh, Alok K.,Zhang, Chun,Carvalho, Jose,Rajan, Srinivan,Amaral, Adam,Beil, Michael E.,Fu, Fumin,Gangl, Eric,Hu, Chii-Whei,Jeng, Arco Y.,LaSala, Daniel,Liang, Guiqing,Logman, Michael,Maniara, Wieslawa M.,Rigel, Dean F.,Smith, Sherri A.,Ksander, Gary M.

, p. 4749 - 4770 (2015/06/25)

CYP11B2, the aldosterone synthase, and CYP11B1, the cortisol synthase, are two highly homologous enzymes implicated in a range of cardiovascular and metabolic diseases. We have previously reported the discovery of LCI699, a dual CYP11B2 and CYP11B1 inhibi

Substituted Diphenylethers, -Amines, -Sulfides and -Methanes for the Treatment of Respiratory Disease

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Page/Page column 21, (2009/01/20)

The invention relates to substituted diphenylethers, -amines, -sulfides, and -methanes as useful pharmaceutical compounds for treating respiratory-disorders, pharmaceutical compositions containing them, and processes for their preparation.

ORGANIC COMPOUNDS

-

Page/Page column 68-69, (2008/06/13)

The present invention provides a compound of formula (I):said compound is inhibitor of aldosterone synthase, and thus can be employed for the treatment of a disorder or disease mediated by aldosterone synthase. Accordingly, the compound of formula I can be used in treatment of hypokalemia, hypertension, congestive heart failure, renal failure, in particular, chronic renal failure, restenosis, atherosclerosis, syndrome X, obesity, nephropathy, post-myocardial infarction, coronary heart diseases, increased formation of collagen, cardiac fibrosis and remodeling following hypertension and endothelial dysfunction. Finally, the present invention also provides a pharmaceutical composition.

Design and synthesis of piperidine farnesyltransferase inhibitors with reduced glucuronidation potential

Tanaka, Rieko,Rubio, Almudena,Harn, Nancy K.,Gernert, Douglas,Grese, Timothy A.,Eishima, Jun,Hara, Mitsunobu,Yoda, Nobuyuki,Ohashi, Rui,Kuwabara, Takashi,Soga, Shiro,Akinaga, Shiro,Nara, Shinji,Kanda, Yutaka

, p. 1363 - 1382 (2008/02/13)

The design and synthesis of a novel piperidine series of farnesyltransferase (FTase) inhibitors with reduced potential for metabolic glucuronidation are described. The various substitution and exchange of the phenyl group at the C-2 position of the previously described 2-(4-hydroxy)phenyl-3-nitropiperidine 1a (FTase IC50 = 5.4 nM) resulted in metabolically stable compounds with potent FTase inhibition (14a IC50 = 4.3 nM, 20a IC50 = 3.0 nM, and 50a IC50 = 16 nM). Molecular modeling studies of these compounds complexed with FTase and farnesyl pyrophosphate are also described.

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