33769-07-2

Basic information

• Product Name: 1-TRITYL-1H-IMIDAZOLE-4-METHANOL
• Synonyms: RARECHEM AL BD 0931;4-HYDROXYMETHYL-1H-TRITYLIMIDAZOLE;1-TRITYL-IMIDOZOLE-4-METHANOL;1-TRITYL-1H-IMIDAZOLE-4-METHANOL;(1-TRITYL-1H-IMIDAZOL-4-YL)-METHANOL;4-(Hydroxymethyl)-1-trityl-1H-imidazole;1-(Triphenylmethyl)-4-(hydroxymethyl)imidazole;1-Triphenylmethyl-1H-imidazole-4-methanol
• CAS NO: 33769-07-2
• Molecular Formula: C₂₃H₂₀N₂O
• Molecular Weight: 340.42
• Product Categories: blocks;Imidazoles
• Mol File: 33769-07-2.mol
• Article Data: 75

Chemical Properties

• Melting Point: 226-232
• Boiling Point: 516.1 °C at 760 mmHg
• Flash Point: 265.9 °C
• Appearance: /
• Density: 1.1 g/cm³
• Vapor Pressure: 1.77E-11mmHg at 25°C
• Refractive Index: 1.612
• PKA: 13.61±0.10(Predicted)
• CAS DataBase Reference: 1-TRITYL-1H-IMIDAZOLE-4-METHANOL(CAS DataBase Reference)
• NIST Chemistry Reference: 1-TRITYL-1H-IMIDAZOLE-4-METHANOL(33769-07-2)
• EPA Substance Registry System: 1-TRITYL-1H-IMIDAZOLE-4-METHANOL(33769-07-2)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36/37/39
• Hazardous Substances Data: 33769-07-2(Hazardous Substances Data)

Usage

General Description

1-TRITYL-1H-IMIDAZOLE-4-METHANOL is a chemical compound that belongs to the class of imidazole derivatives. It is commonly used in organic synthesis and pharmaceutical research as a building block for the synthesis of various drugs and bioactive molecules. 1-TRITYL-1H-IMIDAZOLE-4-METHANOL is known for its ability to act as a versatile reagent in the formation of carbon-carbon and carbon-nitrogen bonds, making it a valuable tool in the production of complex organic compounds. Additionally, 1-TRITYL-1H-IMIDAZOLE-4-METHANOL has been studied for its potential therapeutic applications in the treatment of various diseases and disorders, highlighting its significance in the field of medicinal chemistry.

InChI:InChI=1/C23H20N2O/c26-17-22-16-25(18-24-22)23(19-10-4-1-5-11-19,20-12-6-2-7-13-20)21-14-8-3-9-15-21/h1-16,18,26H,17H2

Upstream product

• 76-83-5 trityl chloride 
• 76074-88-9 methyl 1-(triphenylmethyl)-1H-imidazole-4-carboxylate 
• 822-55-9 1H-imidazole-5-methanol 
• 822-55-9 (1H-imidazol-4-yl)methanol 
• 32673-41-9 4-hydroxymethyl-1H-imidazole hydrochloride 
• 32673-41-9 1H-imidazol-5-ylmethanol hydrochloride 
• 53525-60-3 4-carbethoxy-1-triphenyl methyl-1H-imidazole 
• 28697-53-2 D-arabinopyranose 
• 3473-63-0 formamidine acetic acid 
• 121-44-8 triethylamine 

Downstream Products

• 499214-82-3 4-(difluoromethyl)-1-trityl-1H-imidazole 
• 154312-79-5 1-trityl-4-(2-cyanoethyl)imidazole 
• 565446-44-8 3-(1-Trityl-1H-imidazol-4-yl)-propionitrile 
• 497856-18-5 4-[[(1-trityl-1H-imidazol-4-yl)methyl]thio]aniline 
• 473659-21-1 diethyl (1-tritylimidazol-4-yl)methylphosphonate 

Relevant articles and documents

Targeting GRP receptor: Design, synthesis and preliminary biological characterization of new non-peptide antagonists of bombesin

We report the rational design, synthesis, and in vitro preliminary evaluation of a new small library of non-peptide ligands of Gastrin Releasing Peptide Receptor (GRP-R), able to antagonize its natural ligand bombesin (BN) in the nanomolar range of concen

HETEROARYL RHEB INHIBITORS AND USES THEREOF

The present invention provides compounds, compositions thereof, and methods of using the same. Compositions comprising a compound of this invention or a pharmaceutically acceptable derivative thereof and a pharmaceutically acceptable carrier, adjuvant, or vehicle. The amount of the compound in compositions of this invention is such that it is effective to measurably inhibit Rheb, in a biological sample or in a patient.

Synthesis and antiproliferatory activity of ruthenium complexes containing N-heterocyclic carboxylates

Solvates of the complexes Ru2Cl(pic)4(EtOH) (2), Ru(Im-CO2)3 (3), and Ru(Im-CO2)(Im-CO2H)Cl2 (4), were synthesized from reaction of RuCl3·3H2O or K3[RuCl6] with the N-heterocyclic carboxylic acids pyridine-2-carboxylic acid (picolinic acid, Hpic), and imidazole-4-carboxylic acid (Im-CO2H). Crystals of 2–4 could not be grown and hence characterization was done by elemental analysis, NMR, IR, and conductivity data; 2 and 4 were tested for antiproliferatory activity in vitro against a human breast cancer cell line, but were less active than, for example, Ru complexes containing bis-imidazole or 4,4′-biimidazole that we studied previously [see Can. J. Chem. 89 (2011) 948]. Preliminary work with a third potential ligand, 3-nitro-1,2,4-triazole-5-carboxylic acid (abbreviated HCANT), and other nitro heterocyclic compounds is also presented.