1030624-36-2

Basic information

• Product Name: 2-(4-chlorophenyl)-N-(2-hydroxypropyl)acetamide
• Synonyms: 2-(4-chlorophenyl)-N-(2-hydroxypropyl)acetamide
• CAS NO: 1030624-36-2
• Molecular Weight: 227.691
• Mol File: 1030624-36-2.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 443.1±35.0 °C(Predicted)
• Density: 1.214±0.06 g/cm3(Predicted)
• CAS DataBase Reference: 2-(4-chlorophenyl)-N-(2-hydroxypropyl)acetamide(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(4-chlorophenyl)-N-(2-hydroxypropyl)acetamide(1030624-36-2)
• EPA Substance Registry System: 2-(4-chlorophenyl)-N-(2-hydroxypropyl)acetamide(1030624-36-2)

Safety Data

• Hazardous Substances Data: 1030624-36-2(Hazardous Substances Data)

Usage

Uses

4-Chloro-N-(2-hydroxypropyl)benzeneacetamide is used as a reagent in the synthesis of Lorcaserin Hydrochloride (L469890); a novel selective 5-HT2C-receptor agonist for the treatment of obesity.

Upstream product

• 1878-66-6 4-chlorophenylacetic Acid 
• 78-96-6 3-amino-2-propanol 
• 52449-43-1 (4-chloro-phenyl)-acetic acid methyl ester 

Downstream Products

• 847063-13-2 1-[[2-(4-chlorophenyl)ethyl]amino]-2-hydroxypropane 
• 1030624-41-9 1-((4-chlorophenethyl)amino)propan-2-ol hydrochloride 
• 897926-35-1 2-chloro-N-(4-chlorophenethyl)propanamine 
• 953789-37-2 1-[[2-(4-chlorophenyl)ethyl]amino]-2-chloropropane hydrochloride 
• 616201-80-0 (+/-)-Lorcaserin 
• 824430-78-6 (R)-8-chloro-1-methyl-2,3,4,5-tetrahydro-1H-benzo[d]azepine L-(+)-tartrate 

Relevant articles and documents

Niclosin hydrochloride pellet, and preparation method and preparation thereof

A lorcaserin hydrochloride mini-pill is provided. The mini-pill comprises a blank pill core, a medicine loading layer, a slow-release layer and a quick-release layer in order from inside to outside. The medicine loading layer comprises lorcaserin hydrochloride, lactose monohydrate, highly substituted hydroxypropylcellulose and talcum powder. The slow-release layer comprises ethyl cellulose, highly substituted hydroxypropylcellulose, talcum powder and triethyl citrate. The quick-release layer comprises lorcaserin hydrochloride, lactose monohydrate, highly substituted hydroxypropylcellulose and talcum powder. The mass ratio of the sum of the weight of the blank pill core and the weight of the medicine loading layer to the mass of the slow-release layer is 1:(0.25-0.35). The mini-pill comprises the slow-release layer and the quick-release layer, and therefore a medicine can rapidly work and functions of the medicine in a body are prolonged. A preparing method of the lorcaserin hydrochloride mini-pill and a preparation of the lorcaserin hydrochloride mini-pill are also provided.

PROCESSES FOR THE PREPARATION OF LORCASERIN

The present invention relates to stable crystalline Form A of lorcaserin hydrochloride of Formula (IA) and processes for its preparation. The invention also relates to processes for the preparation of lorcaserin and pharmaceutically acceptable salts, solvates and hydrates thereof.