103067-73-8 Usage
Description
GONADOTROPIN-RELEASING HORMONE (1-6) TRIFLUOROACETATE SALT is a synthetic peptide compound that mimics the action of the naturally-occurring hormone gonadotropin-releasing hormone (GnRH). It is commonly used in research and clinical settings to study and manipulate the reproductive system. GnRH plays a vital role in the regulation of the reproductive system by stimulating the release of follicle-stimulating hormone (FSH) and luteinizing hormone (LH) from the pituitary gland. These hormones, in turn, regulate the production of sex hormones such as estrogen and testosterone. The trifluoroacetate salt form of GnRH (1-6) is often used for improved stability and solubility in laboratory and clinical applications.
Used in Research and Clinical Settings:
GONADOTROPIN-RELEASING HORMONE (1-6) TRIFLUOROACETATE SALT is used as a research and clinical tool for studying and manipulating the reproductive system. It is used to stimulate the release of follicle-stimulating hormone (FSH) and luteinizing hormone (LH) from the pituitary gland, which in turn regulate the production of sex hormones such as estrogen and testosterone.
Used in Pharmaceutical Industry:
GONADOTROPIN-RELEASING HORMONE (1-6) TRIFLUOROACETATE SALT is used as a pharmaceutical compound for the development of drugs targeting the reproductive system. It can be used to create medications that help regulate hormone levels and treat various reproductive disorders.
Used in Fertility Treatments:
GONADOTROPIN-RELEASING HORMONE (1-6) TRIFLUOROACETATE SALT is used as a fertility treatment to stimulate the production of eggs and sperm, improving the chances of conception in individuals with fertility issues.
Used in Hormone Replacement Therapy:
GONADOTROPIN-RELEASING HORMONE (1-6) TRIFLUOROACETATE SALT is used as a component in hormone replacement therapy to help regulate hormone levels in individuals experiencing hormonal imbalances or deficiencies.
Check Digit Verification of cas no
The CAS Registry Mumber 103067-73-8 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,0,3,0,6 and 7 respectively; the second part has 2 digits, 7 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 103067-73:
(8*1)+(7*0)+(6*3)+(5*0)+(4*6)+(3*7)+(2*7)+(1*3)=88
88 % 10 = 8
So 103067-73-8 is a valid CAS Registry Number.
103067-73-8Relevant articles and documents
An Approach to the Elucidation of Metabolic Breakdown Products of the Luteinizing Hormone-Releasing Hormone
Stetler-Stevenson, Mary Alice,Yang, Dai Chang,Lipkowski, Andrew,McCartney, Linda,Peterson, Darryl,Fluoret, George
, p. 688 - 692 (2007/10/02)
Metabolic breakdown of the luteinizing hormone-releasing hormone (LH-RH) could lead to the following fragments containing pyroglutamic acid: pyroglutamic acid (1), pGlu-His (2), pGlu-His-Trp (3), pGlu-His-Trp-Ser (4), etc., and finally pGlu-His-Trp-Ser-Tyr-Gly-Leu-Arg-Pro-Gly (10).We have synthesized fragments 2-10 and successfully separated all ten metabolites and LH-RH by high-performance liquid chromatography (HPLC) with μBondapak C18 column.In a test of viability of the method, cochromatography of fragments 1-10 and LH-RH with the products of chymotryptic digestion of tritiated LH-RH showed radioactive peaks corresponding to the expected products, fragments 3 and 5.Analysis of the products of incubation of a rat kidney homogenate supernatant with LH-RH showed fragments 1-4 and LH-RH.The finding of breakdown at position 4 uncovers a new site of LH-RH breakdown and points the way to the design of potential LH-RH antagonists and agonists where the 4 position would be substituted with unnatural amino acids to prevent breakdown.
