195136-65-3

Usage

Uses

Used in Pharmaceutical Industry:
2,4-Dimethoxy-5-fluoroaniline is used as a key intermediate in the synthesis of various pharmaceuticals for its ability to contribute to the development of new drugs with specific therapeutic properties. Its unique molecular structure allows for the creation of compounds with targeted effects on biological systems.
Used in Agrochemical Industry:
In the agrochemical sector, 2,4-Dimethoxy-5-fluoroaniline serves as an intermediate in the production of agrochemicals, including pesticides and herbicides. Its incorporation into these products can enhance their effectiveness in controlling pests and weeds, thereby contributing to increased crop yields and agricultural productivity.
Used in Dye Production:
2,4-Dimethoxy-5-fluoroaniline is utilized in the manufacturing process of dyes due to its chemical properties that facilitate the creation of vibrant and stable colorants. These dyes find applications in various industries, such as textiles, plastics, and printing inks, where colorfastness and resistance to fading are essential.
Used in Optical Brighteners:
2,4-Dimethoxy-5-fluoroaniline is also employed in the production of optical brighteners, which are additives used to enhance the whiteness and brightness of various materials. Optical brighteners work by absorbing ultraviolet light and re-emitting it as visible blue light, thereby creating a brighter appearance. They are commonly used in the paper, textile, and detergent industries to improve the aesthetic qualities of products.

Upstream product

• 2105-61-5 1,2,4-trifluoro-5-nitrobenzene 
• 195136-62-0 1-Fluoro-2,4-dimethoxy-5-nitro-benzene 

Downstream Products

• 17715-70-7 1,3-dimethoxy-4-fluorobenzene 
• 879288-15-0 1-fluoro-5-iodo-2,4-dimethoxybenzene 
• 625119-43-9 1-fluoro-5-isocyanato-2,4-dimethoxybenzene 
• 913689-08-4 2-(2,7-difluoro-3,6-dihydroxy-9H-xanthen-9-yl)benzoic acid 
• 103068-41-3 4-fluororesorcinol 
• 430459-44-2 5,5'-difluoro-2,2',4,4'-tetrahydroxybenzophenone 
• 879288-16-1 bis(5-fluoro-2,4-dimethoxyphenyl)methanone 
• 879288-21-8 N-[4-(2,7-difluoro-6-hydroxy-3-oxo-3H-xanthen-9-yl)-3-methylbenzoyl]-β-alanyl-N-(3-{(3β)-cholest-5-en-3-yl[(2-nitrophenyl)sulfonyl]amino}propyl)-β-alaninamide 
• 952053-74-6 1-{[4-(2,7-difluoro-6-hydroxy-3-oxo-xanthen-9-yl)-3-methylbenzoyl]oxy}pyrrolidine-2,5-dione 
• 879288-14-9 4-(2,7-difluoro-6-hydroxy-3-oxo-3H-xanthen-9-yl)-3-methylbenzoic acid 
• 879288-18-3 4-(2,7-difluoro-6-hydroxy-3-oxo-3H-xanthen-9-yl)-3-methylbenzoic acid methyl ester 

Relevant academic research and scientific papers

The Pennsylvania Green fluorophore: A hybrid of Oregon Green and Tokyo Green for the construction of hydrophobic and pH-insensitive molecular probes

Fluorescent small molecules are powerful tools for exploring cellular biology. As a more hydrophobic, photostable, and less pH-sensitive alternative to fluorescein, we synthesized Pennsylvania Green, a bright, monoanionic fluorophore related to Oregon Gre

Positive allosteric modulators of the nicotinic acetylcholine receptor

The invention provides compounds of Formula I: These compounds may be in the form of pharmaceutical salts or compositions, may be in pure enantiomeric form or racemic mixtures, and are useful in pharmaceuticals used to treat diseases or conditions in which α7 nAChR is known to be involved.

Fluorinated xanthene derivatives

The family of dyes of the invention are fluoresceins and rhodols that are directly substituted on one or more aromatic carbons by fluorine. These fluorine-substituted fluorescent dyes possess greater photostability and have lower sensitivity to pH changes in the physiological range of 6-8 than do non-fluorinated dyes, exhibit less quenching when conjugated to a substance, and possess additional advantages. The dyes of the invention are useful as detectable tracers and for preparing conjugates of organic and inorganic substances.

Synthesis of fluorinated fluoresceins

Several novel fluorinated fluoresceins (Oregon Green dyes) were prepared by the reaction of fluororesorcinols with phthalic anhydride and its derivatives. A novel regiospecific synthesis of fluororesorcinols was key to the successful synthesis of these new fluorophores. (Polyfluoro)- nitrobenzenes were reacted with 2 equiv of sodium methoxide followed by reduction, hydrodediazoniation, and demethylation, giving the first straightforward synthesis of 2-fluororesorcinol, 4-fluororesorcinol, 2,4- difluororesorcinol, and 2,4,5-trifluororesorcinol. These fluorinated fluoresceins have higher photostability and ionize at a lower pH (pK(a) = 3.3-6.1) than fluorescein (pK(a) = 6.5). Some of the fluorinated fluoresceins have very high quantum yields (0.85-0.97), which, in combination with their lower pK(a)s and high photostability, makes them superior fluorescent dyes for use as reporter molecules in biological systems.