1030827-29-2Relevant academic research and scientific papers
Total synthesis of (+)-fostriecin and (+)-phoslactomycin B
Shibahara, Setsuya,Fujino, Masataka,Tashiro, Yasumasa,Okamoto, Nanako,Esumi, Tomoyuki,Takahashi, Keisuske,Ishihara, Jun,Hatakeyama, Susumi
experimental part, p. 2935 - 2953 (2010/03/03)
(+)-Fostriecin and (+)-phoslactomycin B, which are potent and selective inhibitors of protein phosphatase, were synthesized by a highly enantio-and stereoselective approach that enabled us to prepare all possible isomers at both the C11 secondary alcohol position and the δ12-double bond. Georg Thieme Verlag Stuttgart.
Asymmetric total synthesis of (+)-phoslactomycin B
Shibahara, Setsuya,Fujino, Masataka,Tashiro, Yasumasa,Takahashi, Keisuke,Ishihara, Jun,Hatakeyama, Susumi
supporting information; experimental part, p. 2139 - 2142 (2009/07/04)
(Chemical Equation Presented) (+)-Phoslactomycin B was synthesized by a highly enantio- and stereoselective approach involving asymmetric pentenylation, Suzuki-Miyaura coupling, ring-closing metathesis, asymmetric dihydroxylation, and Stille coupling. The synthetic method developed enables us to synthesize three other isomers concerning the C11-OH and Δ12-double bond.
