122856-26-2Relevant academic research and scientific papers
Total synthesis of (+)-fostriecin and (+)-phoslactomycin B
Shibahara, Setsuya,Fujino, Masataka,Tashiro, Yasumasa,Okamoto, Nanako,Esumi, Tomoyuki,Takahashi, Keisuske,Ishihara, Jun,Hatakeyama, Susumi
experimental part, p. 2935 - 2953 (2010/03/03)
(+)-Fostriecin and (+)-phoslactomycin B, which are potent and selective inhibitors of protein phosphatase, were synthesized by a highly enantio-and stereoselective approach that enabled us to prepare all possible isomers at both the C11 secondary alcohol position and the δ12-double bond. Georg Thieme Verlag Stuttgart.
Asymmetric total synthesis of (+)-phoslactomycin B
Shibahara, Setsuya,Fujino, Masataka,Tashiro, Yasumasa,Takahashi, Keisuke,Ishihara, Jun,Hatakeyama, Susumi
supporting information; experimental part, p. 2139 - 2142 (2009/07/04)
(Chemical Equation Presented) (+)-Phoslactomycin B was synthesized by a highly enantio- and stereoselective approach involving asymmetric pentenylation, Suzuki-Miyaura coupling, ring-closing metathesis, asymmetric dihydroxylation, and Stille coupling. The synthetic method developed enables us to synthesize three other isomers concerning the C11-OH and Δ12-double bond.
Total synthesis of phoslactomycin B and its biosynthetic deamino precursor
Wang, Yong-Gang,Takeyama, Ryuichi,Kobayashi, Yuichi
, p. 3320 - 3323 (2008/02/11)
(Chemical Equation Presented) The implicated intermediate in the biosynthesis of phospholine (phoslactomycin B, see picture), namely its deamino precursor, as well as phospholine itself are synthesized. The phoslactomycins show antitumor, antibacterial, a
