122856-26-2

Basic information

• Product Name: Phoslactomycin B
• Synonyms: Phoslactomycin B;6-[[3-(2-Aminoethyl)-10-cyclohexyl-3,6-dihydroxy-4-(phosphonooxy)deca-1,7,9-trien]-1-yl]-5-ethyl-5,6-dihydro-2H-pyran-2-one;6-[3-(2-Aminoethyl)-10-cyclohexyl-3,6-dihydroxy-4-phosphonooxy-1,7,9-decatrienyl]-5-ethyl-5,6-dihydro-2H-pyran-2-one
• CAS NO: 122856-26-2
• Molecular Formula: C25H40NO8P
• Molecular Weight: 513.5608
• Mol File: 122856-26-2.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 753.1°Cat760mmHg
• Flash Point: 409.3°C
• Appearance: /
• Density: 1.309g/cm³
• Vapor Pressure: 3.54E-26mmHg at 25°C
• Refractive Index: 1.614
• CAS DataBase Reference: Phoslactomycin B(CAS DataBase Reference)
• NIST Chemistry Reference: Phoslactomycin B(122856-26-2)
• EPA Substance Registry System: Phoslactomycin B(122856-26-2)

Safety Data

• Hazardous Substances Data: 122856-26-2(Hazardous Substances Data)

Usage

InChI:InChI=1/C25H40NO8P/c1-2-20-12-13-24(28)33-22(20)14-15-25(29,16-17-26)23(34-35(30,31)32)18-21(27)11-7-6-10-19-8-4-3-5-9-19/h6-7,10-15,19-23,27,29H,2-5,8-9,16-18,26H2,1H3,(H2,30,31,32)/b10-6+,11-7+,15-14+

Upstream product

• 902782-26-7 (5S,6S)-6-[(1E,3R,4R,6R,7Z,9Z)-3-(2-(bis(allyloxycarbonyl)amino)ethyl)-10-cyclohexyl-4-(diallyloxyphosphinyl)-3,6-dihydroxydeca-1,7,9-trienyl]-5-ethyl-5,6-dihydro-2H-pyran-2-one 
• 1030827-29-2 allyl {(3R,4R,6R,7Z,9Z)-4-{[bis(allyloxy)phosphoryl]oxy}-10-cyclohexyl-3-{(E)-2-[(2S,3S)-3-ethyl-6-oxo-3,6-dihydro-2H-pyran-2-yl]vinyl}-3,6-dihydroxydeca-7,9-dien-1-yl}carbamate 
• 902782-25-6 (5S,6S)-6-[(1E,3R,4R,6R,7Z,9Z)-3-(2-(bis(allyloxycarbonyl)amino)ethyl)-10-cyclohexyl-4-(diallyloxyphosphinyl)-6-(triethylsilyloxy)-3-(trimethylsilyloxy)deca-1,7,9-trienyl]-5-ethyl-5,6-dihydro-2H-pyran-2-one 
• 902782-24-5 (5S,6S)-6-[(1E,3R,4R,6R,7Z,9Z)-3-(2-(bis(allyloxycarbonyl)amino)ethyl)-10-cyclohexyl-4-hydroxy-6-(triethylsilyloxy)-3-(trimethylsilyloxy)deca-1,7,9-trienyl]-5-ethyl-5,6-dihydro-2H-pyran-2-one 
• 902782-23-4 (5S,6S)-6-[(1E,3R,4R,6R,7Z,9Z)-3-(2-(bis(allyloxycarbonyl)amino)ethyl)-10-cyclohexyl-4-(4-methoxybenzyloxy)-6-(triethylsilyloxy)-3-(trimethylsilyloxy)deca-1,7,9-trienyl]-5-ethyl-5,6-dihydro-2H-pyran-2-one 
• 902782-22-3 (5S,6S)-6-[(1E,3R,4R,6R,7Z,9Z)-10-cyclohexyl-3-(2-hydroxyethyl)-4-(4-methoxybenzyloxy)-6-(triethylsilyloxy)-3-(trimethylsilyloxy)deca-1,7,9-trienyl]-5-ethyl-5,6-dihydro-2H-pyran-2-one 
• 902782-21-2 (5S,6S)-6-[(1E,3R,4R,6R,7Z,9Z)-10-cyclohexyl-4-(4-methoxybenzyloxy)-6-(triethylsilyloxy)-3-(2-(triethylsilyloxy)ethyl)-3-(trimethylsilyloxy)deca-1,7,9-trienyl]-5-ethyl-5,6-dihydro-2H-pyran-2-one 
• 902782-20-1 (5S,6S)-6-[(1E,3R,4R,6R,7Z,9Z)-10-cyclohexyl-3-hydroxy-4-(4-methoxybenzyloxy)-6-(triethylsilyloxy)-3-(2-(triethylsilyloxy)ethyl)deca-1,7,9-trienyl]-5-ethyl-5,6-dihydro-2H-pyran-2-one 
• 902782-19-8 (5S,6S)-6-[(1E,3R,4R,6R,7Z,9Z)-10-cyclohexyl-3,6-dihydroxy-3-(2-hydroxyethyl)-(4-methoxybenzyloxy)deca-1,7,9-trienyl]-5-ethyl-5,6-dihydro-2H-pyran-2-one 
• 902782-18-7 (5S,6S)-6-[(1E,3R,4R,6R,9Z)-10-cyclohexyl-3,6-dihydroxy-3-(2-hydroxyethyl)-(4-methoxybenzyloxy)deca-1,9-dien-7-ynyl]-5-ethyl-5,6-dihydro-2H-pyran-2-one 
• 902782-39-2 (5S,6S)-6-[(1E,3R,4R,6R,9Z)-6-(tert-butyldimethylsiloxy)-3-[2-(tert-butyldiphenylsiloxy)ethyl]-10-cyclohexyl-4-(4-methoxybenzyloxy)-3-(triethylsiloxy)deca-1,9-dien-7-ynyl]-5-ethyl-5,6-dihydro-2H-pyran-2-one 
• 902782-17-6 ethyl (2Z,4S,5S,6E,8R,9R,11R,14Z)-11-(tert-butyldimethylsiloxy)-8-[2-(tert-butyldiphenylsiloxy)ethyl]-15-cyclohexyl-4-ethyl-5-hydroxy-9-(4-methoxybenzyloxy)-8-(triethylsiloxy)pentadeca-2,6,14-trien-12-ynoate 
• 902782-16-5 ethyl (2Z,4S,5S,6E,8R,9R,11R,14Z)-11-(tert-butyldimethylsiloxy)-8-[2-(tert-butyldiphenylsiloxy)ethyl]-15-cyclohexyl-4-ethyl-9-(4-methoxybenzyloxy)-5,8-bis(triethylsiloxy)pentadeca-2,6,14-trien-12-ynoate 
• 902782-38-1 (2R,3S,4E,6R,7R,9R,12Z)-9-(tert-butyldimethylsiloxy)-6-[2-(tert-butyldiphenylsiloxy)ethyl]-13-cyclohexyl-2-ethyl-7-(4-methoxybenzyloxy)-3,6-bis(triethylsiloxy)trideca-4,12-dien-10-ynal 

Relevant articles and documents

Total synthesis of (+)-fostriecin and (+)-phoslactomycin B

(+)-Fostriecin and (+)-phoslactomycin B, which are potent and selective inhibitors of protein phosphatase, were synthesized by a highly enantio-and stereoselective approach that enabled us to prepare all possible isomers at both the C11 secondary alcohol position and the δ12-double bond. Georg Thieme Verlag Stuttgart.

Total synthesis of phoslactomycin B and its biosynthetic deamino precursor

(Chemical Equation Presented) The implicated intermediate in the biosynthesis of phospholine (phoslactomycin B, see picture), namely its deamino precursor, as well as phospholine itself are synthesized. The phoslactomycins show antitumor, antibacterial, a