1030857-86-3Relevant academic research and scientific papers
Design and synthesis of curcumin derivatives as tau and amyloid β dual aggregation inhibitors
Okuda, Michiaki,Hijikuro, Ichiro,Fujita, Yuki,Teruya, Takayuki,Kawakami, Hirochika,Takahashi, Takashi,Sugimoto, Hachiro
, p. 5024 - 5028 (2016/10/05)
Alzheimer's disease (AD) is the most common form of dementia. In an AD patient's brain, senile plaques and neurofibrillary tangles, the abnormal aggregates of amyloid β (Aβ) peptide and tau protein, are observed as the two major hallmarks of this disease.
NOVEL CURCUMIN DERIVATIVE
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Page/Page column 10, (2009/12/07)
The present invention provides a novel compound that is structurally similar to curcumin and has a suppressive effect on Aβ aggregation, a degradative effect on Aβ aggregates, an inhibitory effect on β-secretase, and a protective effect on neurons. The novel compound is a compound represented by the following general formula (Ia) or a salt thereof: wherein R1 represents a 4-hydroxy-3-methoxyphenyl group or the like, and R2 represents a 1H-indol-6-yl group or the like.
