1924-25-0Relevant academic research and scientific papers
Development of curcumin-based amyloid β aggregation inhibitors for Alzheimer's disease using the SAR matrix approach
Asawa, Yasunobu,Ban, Hyun Seung,Nakamura, Hiroyuki,Okada, Satoshi,Yoshimori, Atsushi,Yudi Utomo, Rohmad,Bajorath, Jürgen
, (2021)
Amyloid β (Aβ) aggregation inhibitor activity cliff involving a curcumin structure was predicted using the SAR Matrix method on the basis of 697 known Aβ inhibitors from ChEMBL (data set 2487). Among the compounds predicted, compound B was found to posses
Click chemistry approach to characterize curcumin-protein interactions in vitro and in vivo
Yang, Haixia,Sukamtoh, Elvira,Du, Zheyuan,Wang, Weicang,Ando, Manami,Kwakwa, Yaa Nyamekye,Zhang, Jianan,Zhang, Guodong
, p. 1 - 6 (2019)
Curcumin, a bis-α, β-unsaturated β-diketon dietary compound from turmeric, is among the most promising dietary compounds for preventing chronic diseases. Previous research has shown that curcumin is highly reactive toward protein thiols to form curcumin-p
Feruloyloacetone can be the main curcumin transformation product
Typek, Rafa?,Dawidowicz, Andrzej L.,Bernacik, Katarzyna,Stankevi?, Marek
, p. 136 - 140 (2019)
Curcumin is a phenolic compound produced by some plants, among which Curcuma longa is the reachest in this principal curcuminoid. At elevated temperature curcumin degrades to trans-6-(4′-hydroxy-3′-methoxyphenyl)-2,4-dioxo-5-hexenal, vanillin, ferulic aci
Mitochondrial-targeting curcumin derivative as well as preparation method and medical application thereof
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Paragraph 0074-0076; 0078; 0081-0084; 0085-0088; 0104; ..., (2021/07/21)
The invention relates to the field of natural medicines and medicinal chemistry, in particular to a mitochondria-targeting curcumin derivative. The invention also discloses a preparation method of the curcumin derivative and application of the curcumin de
Curcumin histone deacetylase inhibitor and preparation method and medical application thereof
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Paragraph 0034-0037, (2021/07/24)
The invention relates to the fields of medicinal chemistry and biology, in particular to a curcumin histone deacetylase inhibitor. The invention also discloses a preparation method of the inhibitor and an application of the inhibitor in exerting anti-tumor activity by inhibiting histone deacetylase.
Discovery of novel anti-tumor curcumin analogues from the optimization of curcumin scaffold
Zhang, Laiyin,Zong, Haiyang,Lu, Huiping,Gong, Jingru,Ma, Fenfen
, p. 2468 - 2476 (2017/10/05)
A series of novel curcumin analogues were synthesized by optimization of its aromatic ring. The antiproliferative activities of these analogues were screened against four human cancer cell lines by MTT assay and some displayed significant improvement in a
Lys modification of curcumin derivatives, their synthesis and use
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Paragraph 0037; 0038; 0039, (2018/11/03)
The present invention discloses pseudo-peptides as the following formula, and further discloses a preparation method and applications of the pseudo-peptides. The pseudo-peptides in the invention have an excellent thrombolytic activity, an antithrombotic a
Pharmacological protection of mitochondrial function mitigates acute limb ischemia/reperfusion injury
Bi, Wei,Bi, Yue,Gao, Xiang,Yan, Xin,Zhang, Yanrong,Harris, Jackie,Legalley, Thomas D.,Gibson, K. Michael,Bi, Lanrong
supporting information, p. 4042 - 4051 (2016/08/01)
We describe several novel curcumin analogues that possess both anti-inflammatory antioxidant properties and thrombolytic activities. The therapeutic efficacy of these curcumin analogues was verified in a mouse ear edema model, a rat arterial thrombosis as
Design and synthesis of curcumin derivatives as tau and amyloid β dual aggregation inhibitors
Okuda, Michiaki,Hijikuro, Ichiro,Fujita, Yuki,Teruya, Takayuki,Kawakami, Hirochika,Takahashi, Takashi,Sugimoto, Hachiro
, p. 5024 - 5028 (2016/10/05)
Alzheimer's disease (AD) is the most common form of dementia. In an AD patient's brain, senile plaques and neurofibrillary tangles, the abnormal aggregates of amyloid β (Aβ) peptide and tau protein, are observed as the two major hallmarks of this disease.
Synthesis and evaluation of curcumin derivatives toward an inhibitor of beta-site amyloid precursor protein cleaving enzyme 1
Konno, Hiroyuki,Endo, Hitoshi,Ise, Satomi,Miyazaki, Keiki,Aoki, Hideo,Sanjoh, Akira,Kobayashi, Kazuya,Hattori, Yasunao,Akaji, Kenichi
supporting information, p. 685 - 690 (2014/01/23)
To research a new non-peptidyl inhibitor of beta-site amyloid precursor protein cleaving enzyme 1, we focused on the curcumin framework, two phenolic groups combined with an sp2 carbon spacer for low-molecular and high lipophilicity. The structure-activity relationship study of curcumin derivatives is described. Our results indicate that phenolic hydroxy groups and an alkenyl spacer are important structural factors for the inhibition of beta-site amyloid precursor protein cleaving enzyme 1 and, furthermore, non-competitive inhibition of enzyme activity is anticipated from an inhibitory kinetics experiment and docking simulation.
