1924-25-0Relevant articles and documents
Development of curcumin-based amyloid β aggregation inhibitors for Alzheimer's disease using the SAR matrix approach
Asawa, Yasunobu,Ban, Hyun Seung,Nakamura, Hiroyuki,Okada, Satoshi,Yoshimori, Atsushi,Yudi Utomo, Rohmad,Bajorath, Jürgen
, (2021)
Amyloid β (Aβ) aggregation inhibitor activity cliff involving a curcumin structure was predicted using the SAR Matrix method on the basis of 697 known Aβ inhibitors from ChEMBL (data set 2487). Among the compounds predicted, compound B was found to posses
Feruloyloacetone can be the main curcumin transformation product
Typek, Rafa?,Dawidowicz, Andrzej L.,Bernacik, Katarzyna,Stankevi?, Marek
, p. 136 - 140 (2019)
Curcumin is a phenolic compound produced by some plants, among which Curcuma longa is the reachest in this principal curcuminoid. At elevated temperature curcumin degrades to trans-6-(4′-hydroxy-3′-methoxyphenyl)-2,4-dioxo-5-hexenal, vanillin, ferulic aci
Curcumin histone deacetylase inhibitor and preparation method and medical application thereof
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Paragraph 0034-0037, (2021/07/24)
The invention relates to the fields of medicinal chemistry and biology, in particular to a curcumin histone deacetylase inhibitor. The invention also discloses a preparation method of the inhibitor and an application of the inhibitor in exerting anti-tumor activity by inhibiting histone deacetylase.