103123-47-3

Upstream product

• 186581-53-3 diazomethane 
• 261159-45-9 (R)-4-(2-phenylethyl)oxetane-2-one 
• 482371-82-4 methyl (R)-3-azido-5-phenylpentanoate 
• 508225-75-0 (R)-3-((R)-2-Methyl-propane-2-sulfinylamino)-5-phenyl-pentanoic acid methyl ester 
• 104-53-0 3-phenyl-propionaldehyde 
• 1412429-46-9 dimethyl [(1R)-1-{[(R)-(tert-butyl)sulfinyl]amino}-3-phenylpropyl]propanedioate 
• 482371-80-2 (R)-3-Azido-5-phenyl-pentanoic acid 
• 336105-29-4 (R_S,E)-(-)-N-(3-phenylpropyl)idene-tert-butanesulfinamide 

Downstream Products

• 508225-76-1 (S)-3-((S)-2-Benzyloxycarbonylamino-3-phenyl-propionylamino)-5-phenyl-pentanoic acid methyl ester 
• 508225-67-0 {(S)-1-[(S)-1-(2-Hydroxy-ethyl)-3-phenyl-propylcarbamoyl]-2-phenyl-ethyl}-carbamic acid benzyl ester 
• 570376-96-4 Thioacetic acid S-[(S)-3-((S)-2-benzyloxycarbonylamino-3-phenyl-propionylamino)-5-phenyl-pentyl] ester 

Relevant academic research and scientific papers

Diastereoselective coupling of N-(tert-Butyl)sulfinyl imines and dimethyl malonate. Synthesis of enantiomerically enriched β-amino esters and β-lactams

A diastereoselective coupling of dimethyl malonate with N-(tert-butyl)sulfinyl imines under solvent-free conditions was developed, using NaHCO3 or NaI as base promoters. The resulting dimethyl 2-(1-aminoalkyl)malonates could be easily transformed successively to β-amino esters and the corresponding β-lactams with high optical purity. Copyright

Diastereoselective coupling of N-(tert-Butyl)sulfinyl imines and dimethyl malonate. Synthesis of enantiomerically enriched β-amino esters and β-lactams

A diastereoselective coupling of dimethyl malonate with N-(tert-butyl)sulfinyl imines under solvent-free conditions was developed, using NaHCO3 or NaI as base promoters. The resulting dimethyl 2-(1-aminoalkyl)malonates could be easily transformed successively to β-amino esters and the corresponding β-lactams with high optical purity. Copyright

Crystal structures of reversible ketone-Based inhibitors of the cysteine protease cruzain

The crystal structures of two hydroxymethyl ketone inhibitors complexed to the cysteine protease cruzain have been determined at 1.1 and 1.2 A resolution, respectively. These high resolution crystal structures provide the first structures of non-covalent inhibitors bound to cruzain. A series of compounds were prepared and tested based upon the structures providing further insight into the key binding interactions.

Divergent reaction pathways in amine additions to β-lactone electrophiles. An application to β-peptide synthesis

β-Lactone electrophiles are subject to regioselective addition-elimination (AE) or SN2 ring opening with various nitrogen-based nucleophiles. Primary and secondary amines promote AE ring opening to deliver products that are the functional equiv