508225-75-0

Upstream product

• 79-20-9 acetic acid methyl ester 
• 336105-29-4 (R_S,E)-(-)-N-(3-phenylpropyl)idene-tert-butanesulfinamide 
• 104-53-0 3-phenyl-propionaldehyde 

Downstream Products

• 570376-96-4 Thioacetic acid S-[(S)-3-((S)-2-benzyloxycarbonylamino-3-phenyl-propionylamino)-5-phenyl-pentyl] ester 
• 508225-76-1 (S)-3-((S)-2-Benzyloxycarbonylamino-3-phenyl-propionylamino)-5-phenyl-pentanoic acid methyl ester 
• 508225-67-0 {(S)-1-[(S)-1-(2-Hydroxy-ethyl)-3-phenyl-propylcarbamoyl]-2-phenyl-ethyl}-carbamic acid benzyl ester 
• 103123-47-3 methyl (3R)-3-amino-5-phenylpentanoate 

Relevant academic research and scientific papers

Crystal structures of reversible ketone-Based inhibitors of the cysteine protease cruzain

The crystal structures of two hydroxymethyl ketone inhibitors complexed to the cysteine protease cruzain have been determined at 1.1 and 1.2 A resolution, respectively. These high resolution crystal structures provide the first structures of non-covalent inhibitors bound to cruzain. A series of compounds were prepared and tested based upon the structures providing further insight into the key binding interactions.