1031417-77-2

Usage

Uses

1. Used in Pharmaceutical Industry:
1-Methylindazole-6-carboxylic acid is used as a building block for the synthesis of various pharmaceutical compounds due to its stable aromatic heterocyclic structure. Its unique chemical properties allow for the creation of new drugs with potential therapeutic applications.
2. Used in Chemical Research:
1-Methylindazole-6-carboxylic acid is used as a research compound in the field of organic chemistry, particularly in the study of indazole derivatives and their potential applications in various chemical reactions and processes.
3. Used in Material Science:
1-Methylindazole-6-carboxylic acid is used as a component in the development of new materials with specific properties, such as conductivity, stability, or reactivity, which can be utilized in various industries, including electronics and energy storage.

Upstream product

• 1007219-73-9 1-methyl-1H-indazole-6-carboxylic acid methyl ester 
• 57848-46-1 4-bromo-2-fluorobenzaldehyde 
• 170487-40-8 1H-indazole-6-carboxylic acid methyl ester 
• 74-88-4 methyl iodide 

Relevant academic research and scientific papers

Synthetic method 1 - methyl - 111H-indazole -6 - formic acid (by machine translation)

The invention provides a synthetic method, 1 - methyl - 111H-indazole -6 - formic acid. The synthesis method comprises 2 - fluorine -4 - bromobenzaldehyde and methylhydrazine as a raw material, and after the cyclization reaction is carried out 6 - bromo -1 - methyl indazole, then formate esterification reaction and hydrolysis reaction, and the 1 - methyl - 111H (indazole -6 - formic acid; isomers, and the like 1 are avoided, and the problem that impurities are difficult to remove in follow-up separation is avoided. Not only is the product purity, the yield of ring-forming 85% reaction can also reach the unitunits ?, the yield is higher, the product is suitable for small-scale preparation in laboratories, production, reaction conditions are easy to operate, control, production cost, and large-scale industrial production are facilitated. (by machine translation)

ORNITHINE DERIVATIVE

Provided is a compound which is useful as a therapeutic agent for chronic renal insufficiency and a therapeutic agent for diabetic nephropathy. The present inventors have made extensive studies on an ornithine derivative having an antagonistic action against an EP4 receptor, and as a result, they have found that by introducing cycloalkanediyl at a C terminal of the ornithine part of the compound of the present invention, the physicochemical properties such as solubility, and the like can be improved, thereby giving further preferred properties as a pharmaceutical. Therefore, they have completed the present invention. The compound of the present invention exhibits a good antagonistic action against an EP4 receptor, and thus, it is useful as a therapeutic agent for chronic renal insufficiency and diabetic nephropathy.

SPIROKETONE ACETYL-COA CARBOXYLASE INHIBITORS

The invention provides compounds of Formula (1) or a pharmaceutically acceptable salt of said compound, wherein R1, R2, R3, R4, R5, R6, R7, R8 and R9 are as described herein; pharmaceutical compositions thereof; and the use thereof in treating mammals suffering from the condition of being overweight.