1-Methylindazole-6-carboxylic acid

Base Information

• Chemical Name: 1-Methylindazole-6-carboxylic acid
• CAS No.: 1031417-77-2
• Molecular Formula: C9H8N2O2
• Molecular Weight: 176.17202
• Hs Code.: 2933990090
• Mol file: 1031417-77-2.mol

Synonyms:1-Methylindazole-6-carboxylic acid;1-Methyl-1H-indazol-6-carboxylic acid;1H-Indazole-6-carboxylic acid, 1-methyl-

Chemical Property of 1-Methylindazole-6-carboxylic acid

Chemical Property:

• Boiling Point: 383.7±15.0 °C(Predicted)
• PKA: 4.10±0.30(Predicted)
• PSA: 55.12000
• Density: 1.35±0.1 g/cm3(Predicted)
• LogP: 1.27150

Purity/Quality:

99%, ^*data from raw suppliers

1-Methyl-1H-indazole-6-carboxylicacid 98+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-Methylindazole-6-carboxylic acid

There total 5 articles about 1-Methylindazole-6-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

1-methyl-1H-indazole-6-carboxylic acid methyl ester (1007219-73-9) + methyl iodide (74-88-4) → 1-methyl-1H-indazole-6-carboxylic acid (1031417-77-2)

Guidance literature:

1-methyl-1H-indazole-6-carboxylic acid methyl ester; With sodium hydroxide; water;

methyl iodide; Heating / reflux;

Reference yield: 71.0%

1-methyl-1H-indazole-6-carboxylic acid methyl ester (1007219-73-9) → 1-methyl-1H-indazole-6-carboxylic acid (1031417-77-2)

Guidance literature:

With methanol; sodium hydroxide; In water; at 5 - 25 ℃; for 20h; Temperature;

Reference yield:

1H-indazole-6-carboxylic acid methyl ester (170487-40-8) → 1-methyl-1H-indazole-6-carboxylic acid (1031417-77-2)

Guidance literature:

Multi-step reaction with 2 steps

1.1: sodium hexamethyldisilazane / tetrahydrofuran

1.2: Heating / reflux

2.1: sodium hydroxide; water

2.2: Heating / reflux

With sodium hydroxide; water; sodium hexamethyldisilazane; In tetrahydrofuran;

upstream raw materials:

1-methyl-1H-indazole-6-carboxylic acid methyl ester

methyl iodide

1H-indazole-6-carboxylic acid methyl ester

4-bromo-2-fluorobenzaldehyde

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