10316-54-8

Upstream product

• 4233-33-4 4-Phenyl-1,2,4-triazolidine-3,5-dione 
• 3806-59-5 1,3-cyclooctadiene 
• 15988-11-1 4-Phenylurazole 

Downstream Products

• 21178-49-4 4-phenyl-2,4,6-triazatricyclo<5.4.2.0^2,6>tridecane-3,5-dione 
• 82353-45-5 <12,13-²H₂>-4-phenyl-2,4,6-triazatricyclo<5.4.2.0^2,6>tridecane-3,5-dione 
• 3710-30-3 1,7-Octadiene 
• 123797-09-1 (E,E)-1,8-bisphenylsulphonylocta-1,7-diene 
• 32634-64-3 7,8-diazabicyclo<4.2.2>dec-7-ene 
• 931-88-4 cis-Cyclooctene 
• 195197-79-6 N-((1S,2S,3R,4R)-2,3-Dihydroxy-4-phenylacetylamino-cyclooctyl)-2-phenyl-acetamide 
• 1055039-21-8 N-((1R,2R,3S,4S)-4-Amino-2,3-dihydroxy-cyclooctyl)-2-phenyl-acetamide 

Relevant academic research and scientific papers

Biocatalysis in the chiral recognition of meso-diamides - An efficient route from cyclic olefinic hydrocarbons to optically pure diamino-polyols

meso-Diamino-di(tri,tetr)ols 1-8 were synthesized starting from cheap carbocyclic olefins and cis-diepoxy derivatives. Enantioselective hydrolysis of the corresponding bis(phenylacet)amides with penicillin amidase from E. coli (EC 3.5.1.11) was effected in good yields (73-90%) and with high optical purities (ee 91 - >97).

Synthetic studies on 4,5-dihydro-3H-1,2,4-triazole-3,5-diones bearing fluorogenic residues at N-4

A number of fluorescent 4,5-dihydro-3H-1,2,4-triazole-3,5-diones have been made. Intra-inter-electrophilic substitution by the triazoledione moiety on the activated naphthalene ring of 4-[6-(5-dimethylamino-1-naphthylsulfonamido)hexyl]-4,5-dihydro-3H-1,2,4- triazole-3,5-dione 4a3 leads to rapid decomposition. The dienophilicity of the triazoledione moiety in 4-pyren-1-yl-4,5-dihydro-3H-1,2,4-triazole-3,5-dione 4d is dramatically lowered by steric shielding. Insertion of a three-carbon spacer unit into the latter compound, to give the 3-pyren-1-ylpropyl analogue 4e, affords a valuable fluorogenic reagent for the analysis of trace levels of 1,3-dienes. Powdered barium manganate is shown to be an excellent solid-phase oxidant for conversion of urazoles into 1,2,4-triazole-3,5-diones.

Deazetation of a Bicyclic Azo Compound: Resolution of a Stereochemical Ambiguity and Conformational Analysis of a Biradical

Development of a new approach has permitted a fuller analysis of the stereochemistry of deazetation of the stereospecifically deuteriated azo compound (1d) than could be achieved previously, in that it has proved possible to analyse 2H2>octa-1,7-diene for E,E-, E,Z,-and Z,Z-content.This has given results for the thermal and photochemical reactions that can be rationalised in terms of partial conformational equilibration of the biradical.