103174-01-2Relevant academic research and scientific papers
A practical ruthenium-catalyzed cleavage of the allyl protecting group in amides, lactams, imides, and congeners
Alcaide, Benito,Almendros, Pedro,Alonso, Jose M.
, p. 2874 - 2879 (2008/02/03)
A convenient methodology for the deprotection of N-allylic amide-like moieties was developed. The first examples accounting for the ruthenium-catalyzed deallylation of amides, lactams, imides, pyrazolidones, hydantoins, and oxazolidinones have been achieved by the sequential use of Grubbs carbene (isomerization step) and RuCl3 (oxidation step). A variety of substrates, including enantiopure multifunctional β- and γ-lactams, can be employed.
Studies on Lactams. 81. Enantiospecific Synthesis and Absolute Configuration of Substituted β-Lactams from D-Glyceraldehyde Acetonide
Wagle, Dilip R.,Garai, Chandra,Chiang, Julian,Monteleone, Michael G.,Kurys, Barbara E.,et al.
, p. 4227 - 4236 (2007/10/02)
Optically active 3,4-disubstituted 2-azetidinones have been prepared in good yield by the annelation of Schiff bases from D-glyceraldehyde acetonide with acid chlorides (or equivalent) and triethylamine.The utility of this enantiospecific synthesis was ex
Absolute Configuration of α-Substituted β-Lactams from D-Glyceraldehyde Acetonide
Bose, Ajay K.,Hegde, Vinod R.,Wagle, Dilip R.,Bari, Shamsher S.,Manhas, Maghar S.
, p. 161 - 163 (2007/10/02)
3,4-Disubstituted-1-arylazetidin-2-ones can be prepared in an enantiospecific manner by the annelation of Schiff bases from optically active glyceraldehyde acetonide and their stereochemistry determined from n.m.r. studies on lactones prepared from these
