1031797-20-2Relevant academic research and scientific papers
Synthesis of novel bis(β-lactam)-1,3-diynes by copper-promoted homo- or cross-coupling of alkynyl-2-azetidinones
Alcaide, Benito,Almendros, Pedro,Carrascosa, Rocio,Rodriguez-Acebes, Raquel
experimental part, p. 1575 - 1581 (2009/04/11)
Cu(OAc)2 in combination with K2CO3 (a solid base instead of an amine) was proven to be an extremely effective system for promoting the homocoupling of various (β-lactam)acetylenes to afford C2-symmetrical bis(β-lactam)-1,3-diynes, whereas these 2-azetidinone-tethered alkynes underwent the Cadiot-Chodkiewicz cross-coupling reaction with different 2-azetidinone bromoalkynes to form a variety of unsymmetrical bis(β-lactam)diynes in good yields. In addition to their potential biological activity, the resulting enantiopure bis(β-lactam)-1,3- diynes can be converted into bis(β-amino ester)-1,3-diynes, which may find use as macrocyclic cavities, as well as chiral ligands. Wiley-VCH Verlag GmbH & Co. KGaA, 2008.
