444083-12-9Relevant academic research and scientific papers
Additions of allenyl/propargyl organometallic reagents to 4-oxoazetidine-2-carbaldehydes: Novel palladium-catalyzed domino reactions in allenynes
Alcaide, Benito,Almendros, Pedro,Aragoncillo, Cristina
, p. 1719 - 1729 (2002)
Metal-mediated carbonyl allenylation and propargylation of 4-oxoazetidine-2-carbaldehydes were investigated in aqueous environment. Different propargyl bromide and metal promoters showed varied regio- and stereoselectivities on product formation. In addit
Metal-catalyzed cycloisomerization and tandem oxycyclization/hydroxylation of alkynols: Synthesis of nonfused, spiranic and fused oxabicyclic β-lactams
Alcaide, Benito,Almendros, Pedro,Del Campo, Teresa Martinez,Carrascosa, Rocio
scheme or table, p. 4912 - 4919 (2010/10/19)
2-Azetidinone-tethered alkynols, readily prepared from the corresponding aldehydes or ketones, were used as starting materials for the oxycyclization reaction catalyzed by precious metals. AgOAc exclusively affords dihydrofurans, methylenetetrahydrofurans, or methylenetetrahydro-2H-pyrans through specific 5-endo, 5-exo, or 6-exo pathways, respectively. Interestingly, in the presence of a catalytic amount: of PtII or AuIII salts, cyclization reactions occurred preferentially through a tandem oxycyclization/hydroxylation of alkynols to afford a variety of nonfused, spiranic and fused oxabicyclic β-lactams in moderate to high yields. Besides, it has been observed that the tandem gold-catalyzed cycloetherification/hydroxylation of a methoxymethyl alkynyl ether can be accomplished.
New aspects of the indium chemistry of carbonyl-β-lactams
Alcaide, Benito,Almendros, Pedro,Aragoncillo, Cristina,Rodri?guez-Acebes, Raquel
, p. 1163 - 1170 (2007/10/03)
Reactions of racemic as well as optically pure carbonyl-β-lactams with stabilized organo-indium reagents were investigated in aqueous media. The regio- and stereochemistry of the processes were generally good, offering a convenient asymmetric entry to den
