103185-33-7

Basic information

• Product Name: 2-Thiophenecarboxamide,N-methoxy-(9CI)
• Synonyms: 2-Thiophenecarboxamide,N-methoxy-(9CI)
• CAS NO: 103185-33-7
• Molecular Formula: C₆H₇NO₂S
• Molecular Weight: 157.19028
• Product Categories: AMIDE
• Mol File: 103185-33-7.mol
• Article Data: 8

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 2-Thiophenecarboxamide,N-methoxy-(9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Thiophenecarboxamide,N-methoxy-(9CI)(103185-33-7)
• EPA Substance Registry System: 2-Thiophenecarboxamide,N-methoxy-(9CI)(103185-33-7)

Safety Data

• Hazardous Substances Data: 103185-33-7(Hazardous Substances Data)

Upstream product

• 527-72-0 2-thiophenylcarboxylic acid 
• 5271-67-0 2-Thiophenecarbonyl chloride 
• 593-56-6 N-methoxylamine hydrochloride 

Downstream Products

• 1268451-43-9 (E)-3-styrylthiophene-2-carboxamide 
• 1360651-35-9 4,5-diphenylthieno[2,3-c]pyridin-7(6H)-one 
• 15950-35-3 N-(4-chlorophenyl)thiophene-2-carboxamide 
• 39880-80-3 N-(4-methylphenyl)thiophene-2-carboxamide 
• 5380-42-7 thiophene-2-carboxylic acid methyl ester 
• 1364511-74-9 6-methoxy-4,5-diphenylthieno[2,3-c]pyridin-7(6H)-one 

Relevant articles and documents

Ir(III)-Catalyzed Carbenoid Functionalization of Benzamides: Synthesis of N-Methoxyisoquinolinediones and N-Methoxyisoquinolinones

A mild and efficient Ir(III)-catalyzed C-H carbenoid functionalization strategy has been developed to access N-methoxyisoquinolinediones and N-methoxyisoquinolinones. The reaction proceeds efficiently in high yield at room temperature over a broad range of substrates without requirement of any additional oxidants or a base.

Palladium-Nanoparticles-Catalyzed Oxidative Annulation of Benzamides with Alkynes for the Synthesis of Isoquinolones

A novel method to synthesize isoquinolones via oxidative annulation of N-alkoxy benzamides and alkynes using binaphthyl-stabilized palladium nanoparticles (Pd-BNP) as catalyst has been developed. This methodology affords various isoquinolone derivatives in good to excellent yields with high regioselectivities in the presence of air as oxidant. N-Methoxybenzothioamide was also found to undergo oxidative annulation with alkyne successfully and provided a sulfur analogue of isoquinolones in moderate yields. The Pd-BNP catalyst was easily recovered and reused up to four times without any apparent agglomeration. (Figure presented.).

Mild rhodium(III)-catalyzed C-H allylation with 4-vinyl-1,3-dioxolan-2-ones: Direct and stereoselective synthesis of (E)-allylic alcohols

A rhodium(III)-catalyzed C-H direct allylation reaction with 4-vinyl-1,3-dioxolan-2-ones has been developed. The reaction provides a facile and stereoselective access to substituted-(E)-allylic alcohols under mild and redox-neutral reaction conditions. Olefinic C-H activation is applicable, giving multifunctionalized skipped dienes in good yields. Minimal double-bond migration was observed.