15950-35-3

Basic information

• Product Name: 2-Thiophenecarboxamide, N-(4-chlorophenyl)-
• Synonyms: N-(4-chlorophenyl)-2-thiophenecarboxamide
• CAS NO: 15950-35-3
• Molecular Formula: C₁₁H₈ClNOS
• Molecular Weight: 237.70532
• Mol File: 15950-35-3.mol
• Article Data: 7

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 2-Thiophenecarboxamide, N-(4-chlorophenyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Thiophenecarboxamide, N-(4-chlorophenyl)-(15950-35-3)
• EPA Substance Registry System: 2-Thiophenecarboxamide, N-(4-chlorophenyl)-(15950-35-3)

Safety Data

• Hazardous Substances Data: 15950-35-3(Hazardous Substances Data)

Upstream product

• 2810-04-0 Ethyl thiophene-2-carboxylate 
• 106-47-8 4-chloro-aniline 
• 103185-33-7 N-methoxy-1H-thiophene-2-carboxamide 
• 1679-18-1 4-Chlorophenylboronic acid 
• 100-00-5 4-chlorobenzonitrile 
• 5813-89-8 2-thiophenylcarboxamide 
• 637-87-6 1-Chloro-4-iodobenzene 
• 527-72-0 2-thiophenylcarboxylic acid 
• 5271-67-0 2-Thiophenecarbonyl chloride 

Downstream Products

• 107366-71-2 N-(4-chlorophenyl)thiophene-2-carbothioamide 

Relevant articles and documents

Iron-catalyzed cross-coupling of N?methoxy amides and arylboronic acids for the synthesis of N-aryl amides

An efficient iron-catalyzed synthesis of N-aryl amides from N?methoxy amides and arylboronic acids is developed. FeCl3 is used as the sole catalyst for the cross-coupling reaction between N?methoxy amides and arylboronic acids without any other

Design, synthesis, MTT assay, DNA interaction studies of platinum(II) complexes

The square planar Pt(II) complexes of the type [Pt(Ln)(Cl2)] (where Ln?=?L1?3?=?thiophene-2-carboxamide derivatives and L4?6?=?thiophene-2-carbothioamide derivatives) have been synthesized and characterized by physicochemical and various spectroscopic studies. MIC method was employed to inference the antibacterial potency of complexes in reference to free ligands and metal salt. Characteristic binding constant (Kb) and binding mode of complexes with calf thymus DNA (CT-DNA) were determined using absorption titration (0.76–1.61?×?105?M?1), hydrodynamic chain length assay and fluorescence quenching analysis, deducing the partial intercalative mode of binding. Molecular docking calculation displayed free energy of binding in the range of –260.06 to –219.63 kJmol?1. The nuclease profile of complexes towards pUC19 DNA shows that the complexes cleave DNA more efficiently compared to their respective metal salt. Cytotoxicity profile of the complexes on the brine shrimp shows that all the complex exhibit noteworthy cytotoxic activity with LC50 values ranging from 7.87 to 15.94?μg/mL. The complexes have been evaluated for cell proliferation potential in human colon carcinoma cells (HCT 116) and IC50 value of complexes by MTT assay (IC50?=?125–1000?μg/mL).

Determination of aromaticity indices of thiophene and furan by nuclear magnetic resonance spectroscopic analysis of their anilides

A series of m- and p-substituted anilides of benzoic acid, 2-thienoic acid, and 2-furoic acid were prepared and their 1H and 13C nmr spectroscopic characteristics were examined. In general, good correlations were observed between the chemical shifts of proton and carbon signals of the acyl aromatic rings and the Hammett σ. Plots of the chemical shift values of the carbonyl carbons of the benzanilides against those of the 2-thienamides and 2-furamides gave an excellent correlation and the values of the slopes are 0.79 and 0.52, respectively, in dimethyl sulfoxide-d6. The slopes could be considered as a set of aromaticity index.