1031850-23-3Relevant academic research and scientific papers
A Versatile Room-Temperature Route to Di- and Trisubstituted Allenes Using Flow-Generated Diazo Compounds
Poh, Jian-Siang,Tran, Duc N.,Battilocchio, Claudio,Hawkins, Joel M.,Ley, Steven V.
, p. 7920 - 7923 (2015)
A copper-catalyzed coupling reaction between flow-generated unstabilized diazo compounds and terminal alkynes provides di- and trisubstituted allenes. This extremely mild and rapid transformation is highly tolerant of several functional groups. Well tolerated: A mild copper-catalyzed coupling reaction between unstabilized diazo compounds (generated in flow) and terminal alkynes is reported. The method provides di- and trisubstituted allenes with high functional-group tolerance.
