1032008-74-4 Usage
General Description
Endoxifen HCl, also known as 4-hydroxy-N-desmethyltamoxifen hydrochloride, is a selective estrogen receptor modulator (SERM) that is related to the breast cancer drug tamoxifen. Endoxifen HCl is a metabolite of tamoxifen and is more potent in terms of its estrogen receptor binding and anti-estrogenic properties. It is being investigated as a potential alternative treatment for breast cancer, particularly in patients who do not respond well to tamoxifen. Additionally, research suggests that Endoxifen HCl may be effective in preventing the development of breast cancer in high-risk individuals. Further studies are ongoing to determine the safety and efficacy of Endoxifen HCl in clinical settings.
Check Digit Verification of cas no
The CAS Registry Mumber 1032008-74-4 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,0,3,2,0,0 and 8 respectively; the second part has 2 digits, 7 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 1032008-74:
(9*1)+(8*0)+(7*3)+(6*2)+(5*0)+(4*0)+(3*8)+(2*7)+(1*4)=84
84 % 10 = 4
So 1032008-74-4 is a valid CAS Registry Number.
1032008-74-4Relevant articles and documents
A convenient synthesis of (Z)-4-hydroxy-N-desmethyltamoxifen (endoxifen)
Fauq, Abdul H.,Maharvi, Ghulam M.,Sinha, Dola
, p. 3036 - 3038 (2010)
A mixture of the (Z)- and (E)-isomers of 4-hydroxy-N-desmethyltamoxifen was conveniently prepared in four steps. These geometrical isomers were then neatly separated by semi-preparative Reverse Phase High Performance Liquid Chromatography (RP-HPLC) using specified conditions. Additionally, the isolated E-isomer could be equilibrated in aqueous strong acid in acetonitrile or trifluoroacetic acid/dichloromethane to give a clean 1:1 mixture of Z/E isomers that was re-subjected to HPLC separation. In this way, most of the undesired (E)-isomer could be readily converted to the desired (Z)-isomer providing quick access to over 200 mg quantities of pure endoxifen (Z-isomer), a potent antiestrogenic metabolite of tamoxifen traditionally used in breast cancer treatment.
