1032048-34-2Relevant academic research and scientific papers
Expedient entry into 1,4-dihydroquinoxalines and quinoxalines via a novel variant of isocyanide-based MCR
Krasavin, Mikhail,Parchinsky, Vladislav
, p. 645 - 648 (2008)
A novel multicomponent reaction of o-phenylenediamines with aldehydes and isonitriles yields 1,4-dihydroquinoxalines. These intermediates are unstable under reaction conditions. They undergo oxidation with DDQ to furnish 33-54% isolated yields of the respective quinoxalines. This reaction is general for aromatic 1,2-diamines. Monoalkylated aryl 1,2-diamines lead to stable 1,4-dihydroquinoxalines. Georg Thieme Verlag Stuttgart.
