103206-55-9

Upstream product

• 108-24-7 acetic anhydride 
• 60041-30-7 (+/-)-trans-2-methylene-5-t-butylcyclohexanol 

Downstream Products

• 128749-72-4 Acetic acid (1R,2R,5R)-5-tert-butyl-2-hydroxy-2-hydroxymethyl-cyclohexyl ester 
• 128749-72-4 Acetic acid (1S,2R,5S)-5-tert-butyl-2-hydroxy-2-hydroxymethyl-cyclohexyl ester 
• 466635-89-2 (+)-cis-(1R,5R)-2-methylene-5-t-butylcyclohexanol 

Relevant academic research and scientific papers

Diastereoselective and enantioselective lipase-catalyzed hydrolysis of stereoisomeric 2-methylene, 5-t-butylcyclohexyl acetates

cis- and trans-2-Methylene-5-t-butylcyclohexanols are obtained in high (>90%) e.e. through Rabbit Gastric Lipase (RGL)-catalyzed acylation or hydrolysis of the stereoisomeric racemic alcohols or their corresponding acetates. Since these reactions were diastereomer-selective, enantiomerically enriched cis- and trans-5-t-butyl-2-methylenecyclohexanols could also be prepared from cis/trans isomeric mixtures.

Torsional, rotor, and electronic effects in 4-tert-butylmethylenecyclohexane epoxidations and osmylations

The axial epoxidation preference for 2-substituted 4-tert-butylmethylenecyclohexanes is attributed to a combination of small effects, including existing bond torsion and rotor effects. Contributions from developing bond torsion are smaller and may be negl