1032154-55-4Relevant academic research and scientific papers
Br?nsted acid catalyzed asymmetric reduction of 2- and 2,9-substituted 1,10-phenanthrolines
Metallinos, Costa,Barrett, Fred B.,Xu, Shufen
, p. 720 - 724 (2008)
Several 2- and 2,9-substituted 1,10-phenanthrolines are reduced asymmetrically for the first time using a Hantzsch dihydropyridine in the presence of BINOL-derived phosphoric acid catalysts. The best results are obtained with phenanthrolines bearing unbranched or nitrogen-containing alkyl groups in the 2- or 2,9-positions, which afford chiral octahydrophenanthrolines in a range of yields (40-88%) and good to excellent levels of enantiomeric purity (78-99% ee). Georg Thieme Verlag Stuttgart.
