1032290-93-9Relevant academic research and scientific papers
Exploring the differential recognition of DNA G-quadruplex targets by small molecules using dynamic combinatorial chemistry
Bugaut, Anthony,Jantos, Katja,Wietor, Jean-Luc,Rodriguez, Raphael,Sanders, Jeremy K. M.,Balasubramanian, Shankar
, p. 2677 - 2680 (2008/12/23)
Tuning affinities: Dynamic combinatorial chemistry has been employed to explore the effect of chemical modifications on the DNA G-quadruplex binding properties of anoxazole-based peptide macrocycle. Two dynamic libraries of molecules, containing cationic and carbohydrate motifs, respectively, were screened by using structurally diverse nucleic acid targets (see scheme; each colored shape represents a cation or carbohydrate). (Chemical Equation Presented).
