10323-88-3Relevant academic research and scientific papers
Organocatalyst-mediated aldolrobinson cascade reactions: A convenient synthesis of substituted cyclohex-2-enones
Wang, Li,Gong, Qing-Ping,Liu, Xiao-Jun,Li, Yong-Hong,Huang, Ping,Wang, Bi-Qin,Zhao, Ke-Qing
supporting information; experimental part, p. 138 - 139 (2011/04/15)
A convenient organocatalytic process for the chemoselective synthesis of substituted cyclohex-2-enones was developed. The cascade reaction involves a remarkable Michael addition of an acyclic ketone-based enamine onto unmodified enones. The enamine-mediated aldolRobinson cascade reactions of aromatic and aliphatic aldehydes with acetone produced substituted cyclohex-2-enones in moderate to high yields under mild reaction conditions.
