103232-71-9Relevant academic research and scientific papers
THREE-DIMENSIONAL STRUCTURES AND SPECTRA OF 2,6- AND 2,8-DIETHYL-2,4,6,8-TETRAAZABICYCLOOCTANE-3,7-DIONES
Shamuratov, E. B.,Batsanov, A. S.,Struchkov, Yu. T.,Tsivadze, A. Yu.,Tsintsadze, M. G.,et al.
, p. 745 - 749 (1991)
Isomeric 2,6- and 2,8-diethyl-2,4,6,8-tetraazabicyclooctane-3,7-diones were obtained by the reaction of glyoxal with ethyllurea, and their crystal structures and IR, Raman, and PMR spectra were studied.
Preparative synthesis and pharmacological activity of Albicar racemate and enantiomers
Anikina, Lada V.,Vikharev, Yuri B.,Baranov, Vladimir V.,Malyshev, Oleg R.,Kravchenko, Angelina N.
, p. 317 - 319 (2018/06/01)
Racemic Albicar (2,6-diethyl-4,8-dimethylglycoluril) has been synthesized and resolved into enantiomers on a preparative scale by chiral HPLC. A comparison of the pharmacological effects of these compounds has been performed for the first time. It has been demonstrated that the (?)-(1S,5S)-enantiomer exerts a stimulating effect on the central nervous system due to activation of the serotonergic system, since it potentiates the effects of 5-hydroxytryptophan (the serotonin precursor), while the antagonist of serotonin receptors blocks its activity; the (+)-(1R,5R)-enantiomer evinces an inhibitory effect.
Synthesis of new chiral mono-, di-, tri-, and tetraalkylglycolurils
Kravchenko,Sigachev,Maksareva,Gazieva,Trunova,Lozhkin,Pivina,Il'in,Lyssenko,Nelyubina,Davankov,Lebedev,Makhova,Tartakovsky
, p. 691 - 704 (2007/10/03)
Two general procedures were developed for the synthesis of chiral N-mono-, N, N′-di-, N, N′ N″-tri-, and N, N′, N″, N′″-tetraalkylglycolurils based on the reactions of 4,5-dihydroxy-imidazolidin-2-ones or glyoxal with one or two moles of alkylureas, respectively, by acid catalysis. The reactions of N-monoalkyl- and N, N′-dialkylureas with glyoxal proceed regioselectively. The mechanism of these reactions was suggested and partly confirmed by quantum-chemical calculations and experimental data. The enantiomeric separation of some chiral glycolurils by chiral-phase HPLC was carried out for the first time.
